Calcium Based Non-viral Gene Delivery: An Overview of Methodology and Applications
Application of therapeutic gene transfer in the treatment of genetic diseases is a notable progress but there are some disadvantages and limitations in it. The process of overcoming these barriers is a drastic change in gene delivery. Recently, calcium phosphate nanoparticles alone, or in combinatio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2010-05-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/15643.pdf&manuscript_id=15643 |
| _version_ | 1818280650645438464 |
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| author | Kianoush Khosravi-Darani Mohamaad Reza Mozafari Ladan Rashidi Mehrdad Mohammadi |
| author_facet | Kianoush Khosravi-Darani Mohamaad Reza Mozafari Ladan Rashidi Mehrdad Mohammadi |
| author_sort | Kianoush Khosravi-Darani |
| collection | DOAJ |
| description | Application of therapeutic gene transfer in the treatment of genetic diseases is a notable progress but there are some disadvantages and limitations in it. The process of overcoming these barriers is a drastic change in gene delivery. Recently, calcium phosphate nanoparticles alone, or in combination with viral and nonviral vectors, were found to have a positive effect on gene transfer especially when incorporated in the colloidal particulate systems. This review elaborates on various successful methods of using calcium phosphate nanoparticles in gene delivery, which are considered an advancing approach to gene delivery. |
| first_indexed | 2024-12-12T23:52:36Z |
| format | Article |
| id | doaj.art-9608b4fa8e9c4308b43c551ee39b335c |
| institution | Directory Open Access Journal |
| issn | 0044-6025 |
| language | English |
| last_indexed | 2024-12-12T23:52:36Z |
| publishDate | 2010-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-9608b4fa8e9c4308b43c551ee39b335c2022-12-22T00:06:38ZengTehran University of Medical SciencesActa Medica Iranica0044-60252010-05-01483133141Calcium Based Non-viral Gene Delivery: An Overview of Methodology and ApplicationsKianoush Khosravi-DaraniMohamaad Reza MozafariLadan RashidiMehrdad MohammadiApplication of therapeutic gene transfer in the treatment of genetic diseases is a notable progress but there are some disadvantages and limitations in it. The process of overcoming these barriers is a drastic change in gene delivery. Recently, calcium phosphate nanoparticles alone, or in combination with viral and nonviral vectors, were found to have a positive effect on gene transfer especially when incorporated in the colloidal particulate systems. This review elaborates on various successful methods of using calcium phosphate nanoparticles in gene delivery, which are considered an advancing approach to gene delivery.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/15643.pdf&manuscript_id=15643Calcium phosphatenanoparticlesgene transfer techniquestransfection |
| spellingShingle | Kianoush Khosravi-Darani Mohamaad Reza Mozafari Ladan Rashidi Mehrdad Mohammadi Calcium Based Non-viral Gene Delivery: An Overview of Methodology and Applications Acta Medica Iranica Calcium phosphate nanoparticles gene transfer techniques transfection |
| title | Calcium Based Non-viral Gene Delivery: An Overview of Methodology and Applications |
| title_full | Calcium Based Non-viral Gene Delivery: An Overview of Methodology and Applications |
| title_fullStr | Calcium Based Non-viral Gene Delivery: An Overview of Methodology and Applications |
| title_full_unstemmed | Calcium Based Non-viral Gene Delivery: An Overview of Methodology and Applications |
| title_short | Calcium Based Non-viral Gene Delivery: An Overview of Methodology and Applications |
| title_sort | calcium based non viral gene delivery an overview of methodology and applications |
| topic | Calcium phosphate nanoparticles gene transfer techniques transfection |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/15643.pdf&manuscript_id=15643 |
| work_keys_str_mv | AT kianoushkhosravidarani calciumbasednonviralgenedeliveryanoverviewofmethodologyandapplications AT mohamaadrezamozafari calciumbasednonviralgenedeliveryanoverviewofmethodologyandapplications AT ladanrashidi calciumbasednonviralgenedeliveryanoverviewofmethodologyandapplications AT mehrdadmohammadi calciumbasednonviralgenedeliveryanoverviewofmethodologyandapplications |