Prolongation of Anti-Inflammatory Activity of Glucocorticosteroids Encapsulated in Large Oligolamellar Liposomes in Treatment of Arthritis in Rabbits
Background: Liposomes have been shown to be an effective targeted drug delivery system used to decrease side effects of glucocorticosteroids in the treatment of rheumatoid arthritis. Materials and Results: Experimental arthritis was induced in rabbits by a single intra-articular administration int...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Medical Research and Development Corporation
2017-06-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://ijbm.org/articles/IJBM_7(2)_OA9.pdf |
| Summary: | Background: Liposomes have been shown to be an effective targeted drug delivery system used to decrease side effects of glucocorticosteroids in the treatment of rheumatoid arthritis.
Materials and Results: Experimental arthritis was induced in rabbits by a single intra-articular administration into the knee joint of poly-D-lysine (molecular weight, 175 kDa) and hyaluronic acid (7.5 mg per administration). To determine temperature readings over the joint a standard radiator was used with a temperature of 320C. Large oligolamellar liposomes from different phospholipidsand and cholesterol containing hydrocortisone acetate in lipid phase and prednisolone hemisuccinate in water phase were used.
Conclusion: Intra-articular administration of the water-soluble prednisolone hemisuccinate (0.125 mg) and the lipid-soluble hydrocortisone acetate (0.125 mg) into the knee joint in the aqueous and lipid phases of large oligolamellar TSL (DPPC + 20 mole % cholesterol) prolongs the anti-inflammatory effect produced by glucocorticoids by 7–8 days compared to 1 day for free glucocorticosteroids at a total dose of 2.5 mg and 2 days for phosphatidylcholine-cholesterol liposomes at a total dose of 0.25 mg in rabbits with aseptic arthritis. |
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| ISSN: | 2158-0510 2158-0529 |