Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum
Purpose Giant perianal condyloma (GPC) is a rare condition. The effective treatment is a multidisciplinary challenge; topical treatments are usually ineffective, and surgical resection has significant morbidity. Podophyllin at 25% in solid petrolatum (25%PSP) can be an effective treatment option for...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2021-08-01
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| Series: | Journal of Coloproctology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1732329 |
| _version_ | 1818738529598963712 |
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| author | Laura Svidler López Luciana La Rosa Sofía Cipollone Gabriela L. Sidra José L. Regina Rita L. O. Pastore Teresa Orcinoli Elizabeth A. Stier |
| author_facet | Laura Svidler López Luciana La Rosa Sofía Cipollone Gabriela L. Sidra José L. Regina Rita L. O. Pastore Teresa Orcinoli Elizabeth A. Stier |
| author_sort | Laura Svidler López |
| collection | DOAJ |
| description | Purpose Giant perianal condyloma (GPC) is a rare condition. The effective treatment is a multidisciplinary challenge; topical treatments are usually ineffective, and surgical resection has significant morbidity. Podophyllin at 25% in solid petrolatum (25%PSP) can be an effective treatment option for GPC. The aim of the present study was to assess its response and tolerability.
Methods This retrospective, single-center case series evaluated the clinical response of 14 patients with GPC treated with 25%PSP in a public hospital in Buenos Aires between December 2015 and December 2019. After obtaining a full history and performing a physical exam, the lesions were measured and photographed. Biopsies were performed to exclude malignancy, as well as exams to rule out pregnancy. Podophyllin at 25% in solid petrolatum was administered topically in cases of GPC and washed off by the patients at home after 4 hours. The patients underwent at least 4 weekly visits, which included interval history, photodocumentation of the lesions, and provider-applied 25%PSP. The response rate was assessed by comparing measurements and the overall decrease in volume of the GPC based on photos from the first and last sessions. Adverse outcomes were noted.
Results In total, 10 men, 3 women, and 1 transgender woman with GPC unresponsive to prior treatments and a mean age of 34.5 years were included. A total of 12 patients were immunosuppressed. All the perianal lesions were circumferential and measured between 8 cm and 20 cm. Overall, 7 patients had genital condyloma outside of the anus and perianus; the histology showed low-grade squamous intraepithelial lesions in all cases. While on treatment, 7 patients reported dermatitis, and 71% of the patients had ≥ 75% reduction in lesion size.
Conclusions Podophyllin at 25% in solid petrolatum is an effective, well-tolerated topical treatment option for GPC. |
| first_indexed | 2024-12-18T01:10:23Z |
| format | Article |
| id | doaj.art-960b3ef44a674601a371f8bd0fc9f6de |
| institution | Directory Open Access Journal |
| issn | 2237-9363 2317-6423 |
| language | English |
| last_indexed | 2024-12-18T01:10:23Z |
| publishDate | 2021-08-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Journal of Coloproctology |
| spelling | doaj.art-960b3ef44a674601a371f8bd0fc9f6de2022-12-21T21:26:06ZengThieme Revinter Publicações Ltda.Journal of Coloproctology2237-93632317-64232021-08-01410328929410.1055/s-0041-1732329Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid PetrolatumLaura Svidler López0Luciana La Rosa1Sofía Cipollone2Gabriela L. Sidra3José L. Regina4Rita L. O. Pastore5Teresa Orcinoli6Elizabeth A. Stier7Division of Surgery, Hospital Juan A. Fernández, Buenos Aires, ArgentinaCentro Privado de Cirugía y Coloproctología, Buenos Aires, ArgentinaDivision of Surgery, Hospital Juan A. Fernández, Buenos Aires, ArgentinaDivision of Surgery, Hospital Juan A. Fernández, Buenos Aires, ArgentinaDivision of Surgery, Hospital Juan A. Fernández, Buenos Aires, ArgentinaDivision of Surgery, Hospital Juan A. Fernández, Buenos Aires, ArgentinaDivision of Pharmacy, Hospital Juan A. Fernández, Buenos Aires, ArgentinaDepartment of Obstetrics and Gynecology, Boston University School of Medicine, Boston, Massachusetts, United StatesPurpose Giant perianal condyloma (GPC) is a rare condition. The effective treatment is a multidisciplinary challenge; topical treatments are usually ineffective, and surgical resection has significant morbidity. Podophyllin at 25% in solid petrolatum (25%PSP) can be an effective treatment option for GPC. The aim of the present study was to assess its response and tolerability. Methods This retrospective, single-center case series evaluated the clinical response of 14 patients with GPC treated with 25%PSP in a public hospital in Buenos Aires between December 2015 and December 2019. After obtaining a full history and performing a physical exam, the lesions were measured and photographed. Biopsies were performed to exclude malignancy, as well as exams to rule out pregnancy. Podophyllin at 25% in solid petrolatum was administered topically in cases of GPC and washed off by the patients at home after 4 hours. The patients underwent at least 4 weekly visits, which included interval history, photodocumentation of the lesions, and provider-applied 25%PSP. The response rate was assessed by comparing measurements and the overall decrease in volume of the GPC based on photos from the first and last sessions. Adverse outcomes were noted. Results In total, 10 men, 3 women, and 1 transgender woman with GPC unresponsive to prior treatments and a mean age of 34.5 years were included. A total of 12 patients were immunosuppressed. All the perianal lesions were circumferential and measured between 8 cm and 20 cm. Overall, 7 patients had genital condyloma outside of the anus and perianus; the histology showed low-grade squamous intraepithelial lesions in all cases. While on treatment, 7 patients reported dermatitis, and 71% of the patients had ≥ 75% reduction in lesion size. Conclusions Podophyllin at 25% in solid petrolatum is an effective, well-tolerated topical treatment option for GPC.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1732329giant condilomapodophyllintopical treatmenthpvimmunosupression |
| spellingShingle | Laura Svidler López Luciana La Rosa Sofía Cipollone Gabriela L. Sidra José L. Regina Rita L. O. Pastore Teresa Orcinoli Elizabeth A. Stier Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum Journal of Coloproctology giant condiloma podophyllin topical treatment hpv immunosupression |
| title | Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum |
| title_full | Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum |
| title_fullStr | Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum |
| title_full_unstemmed | Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum |
| title_short | Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum |
| title_sort | giant perianal condyloma successfully treated with podophyllin at 25 in solid petrolatum |
| topic | giant condiloma podophyllin topical treatment hpv immunosupression |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1732329 |
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