Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet
Quercetin has been shown to have anti-obesity effects, but it is unknown whether these effects can be transmitted from mothers to their progeny. In this study, we investigated whether maternal quercetin consumption during pregnancy has a protective effect on high-fat diet–induced hyper lipid levels...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/4/1242 |
| _version_ | 1797538271778045952 |
|---|---|
| author | Masakatsu Takashima Wataru Tanaka Hiroki Matsuyama Hayato Tajiri Hiroyuki Sakakibara |
| author_facet | Masakatsu Takashima Wataru Tanaka Hiroki Matsuyama Hayato Tajiri Hiroyuki Sakakibara |
| author_sort | Masakatsu Takashima |
| collection | DOAJ |
| description | Quercetin has been shown to have anti-obesity effects, but it is unknown whether these effects can be transmitted from mothers to their progeny. In this study, we investigated whether maternal quercetin consumption during pregnancy has a protective effect on high-fat diet–induced hyper lipid levels and overweight in progeny. Female mice consumed a control diet or a diet containing 1.0% quercetin during breeding. The male progeny were then divided into four groups that were (1) sacrificed at postnatal day 3; (2) born to dams fed the control diet and also fed the control diet (C-C), (3) born to dams fed the control diet and then fed a 30% high-fat diet (C-HF), or (4) born to dams fed the Q-diet and then fed the HF diet (Q-HF). Maternal consumption of quercetin did not affect body weight or blood lipid parameters in either dams or neonates at postnatal day 3. After 13 weeks, the Q-HF group exhibited greater body and liver weights, and higher blood cholesterol levels than the C-HF group. However, the total cholesterol/ high density lipoprotein (HDL)-cholesterol ratios in the Q-HF and C-C groups remained similar. In conclusion, maternal quercetin consumption does not appear to protect the next generation from high-fat diet–induced hyper cholesterol level in the blood and liver, and consequently overweight, but may help regulate the total cholesterol/HDL-cholesterol ratio. |
| first_indexed | 2024-03-10T12:28:10Z |
| format | Article |
| id | doaj.art-960c27ad8333475d8a6c139e588de39c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T12:28:10Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-960c27ad8333475d8a6c139e588de39c2023-11-21T14:53:19ZengMDPI AGNutrients2072-66432021-04-01134124210.3390/nu13041242Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat DietMasakatsu Takashima0Wataru Tanaka1Hiroki Matsuyama2Hayato Tajiri3Hiroyuki Sakakibara4Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, JapanGraduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, JapanGraduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, JapanGraduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, JapanGraduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, JapanQuercetin has been shown to have anti-obesity effects, but it is unknown whether these effects can be transmitted from mothers to their progeny. In this study, we investigated whether maternal quercetin consumption during pregnancy has a protective effect on high-fat diet–induced hyper lipid levels and overweight in progeny. Female mice consumed a control diet or a diet containing 1.0% quercetin during breeding. The male progeny were then divided into four groups that were (1) sacrificed at postnatal day 3; (2) born to dams fed the control diet and also fed the control diet (C-C), (3) born to dams fed the control diet and then fed a 30% high-fat diet (C-HF), or (4) born to dams fed the Q-diet and then fed the HF diet (Q-HF). Maternal consumption of quercetin did not affect body weight or blood lipid parameters in either dams or neonates at postnatal day 3. After 13 weeks, the Q-HF group exhibited greater body and liver weights, and higher blood cholesterol levels than the C-HF group. However, the total cholesterol/ high density lipoprotein (HDL)-cholesterol ratios in the Q-HF and C-C groups remained similar. In conclusion, maternal quercetin consumption does not appear to protect the next generation from high-fat diet–induced hyper cholesterol level in the blood and liver, and consequently overweight, but may help regulate the total cholesterol/HDL-cholesterol ratio.https://www.mdpi.com/2072-6643/13/4/1242high-fat diet–induced obesitymiceprogenyquercetintotal cholesterol/HDL-cholesterol ratio |
| spellingShingle | Masakatsu Takashima Wataru Tanaka Hiroki Matsuyama Hayato Tajiri Hiroyuki Sakakibara Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet Nutrients high-fat diet–induced obesity mice progeny quercetin total cholesterol/HDL-cholesterol ratio |
| title | Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet |
| title_full | Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet |
| title_fullStr | Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet |
| title_full_unstemmed | Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet |
| title_short | Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet |
| title_sort | maternal quercetin consumption during pregnancy may help regulate total cholesterol hdl cholesterol ratio without effect on cholesterol levels in male progeny consuming high fat diet |
| topic | high-fat diet–induced obesity mice progeny quercetin total cholesterol/HDL-cholesterol ratio |
| url | https://www.mdpi.com/2072-6643/13/4/1242 |
| work_keys_str_mv | AT masakatsutakashima maternalquercetinconsumptionduringpregnancymayhelpregulatetotalcholesterolhdlcholesterolratiowithouteffectoncholesterollevelsinmaleprogenyconsuminghighfatdiet AT watarutanaka maternalquercetinconsumptionduringpregnancymayhelpregulatetotalcholesterolhdlcholesterolratiowithouteffectoncholesterollevelsinmaleprogenyconsuminghighfatdiet AT hirokimatsuyama maternalquercetinconsumptionduringpregnancymayhelpregulatetotalcholesterolhdlcholesterolratiowithouteffectoncholesterollevelsinmaleprogenyconsuminghighfatdiet AT hayatotajiri maternalquercetinconsumptionduringpregnancymayhelpregulatetotalcholesterolhdlcholesterolratiowithouteffectoncholesterollevelsinmaleprogenyconsuminghighfatdiet AT hiroyukisakakibara maternalquercetinconsumptionduringpregnancymayhelpregulatetotalcholesterolhdlcholesterolratiowithouteffectoncholesterollevelsinmaleprogenyconsuminghighfatdiet |