An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo
Objective:Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular system disease causing dizziness. It occurs more in the 5th decade of life and affects the posterior canal in 90% of the patients. The most effective treatment method is canalith repositioning (CRP) maneuv...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2019-12-01
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| Series: | Turkish Archives of Otorhinolaryngology |
| Subjects: | |
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http://turkarchotolaryngol.net/archives/archive-detail/article-preview/an-evaluation-of-the-effects-of-betahistine-and-di/43069
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| _version_ | 1797920140116885504 |
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| author | Hakkı Caner İnan Merve Kıraç |
| author_facet | Hakkı Caner İnan Merve Kıraç |
| author_sort | Hakkı Caner İnan |
| collection | DOAJ |
| description | Objective:Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular system disease causing dizziness. It occurs more in the 5th decade of life and affects the posterior canal in 90% of the patients. The most effective treatment method is canalith repositioning (CRP) maneuver. The aim of this study is to evaluate the effects of betahistine and dimenhydrinate therapies in addition to CRP maneuver on BPPV patients.Methods:The study included 64 patients who had complaints of dizziness and were diagnosed with BPPV by their history and provocation maneuvers. The patients were divided into two groups. In Group 1, only repositioning maneuver was performed. Group 2 was divided into two subgroups. In Group 2a, repositioning maneuver was performed and betahistine 24 mg twice daily was given for 10 days. In Group 2b, repositioning maneuver was performed and dimenhydrinate 50 mg once daily was given for five days. On the 10th day, all patients were reexamined, and provocation maneuver was performed. Dizziness handicap inventory (DHI) was completed and outcomes were reviewed for therapeutic efficacy.Results:Mean DHI scores in all patient groups statistically significantly decreased from a pre-treatment level of 52.16 (range, 20-100) to a post-treatment level of 17.84 (range, 0-78) (p<0.001). No statistically significant differences were found in terms of DHI scores between Group 1 (repositioning maneuver only) and Group 2 (repositioning maneuver plus betahistine or dimenhydrinate).Conclusion:The most effective treatment method of BPPV is repositioning maneuver. Addition of betahistine or dimenhydrinate pharmacotherapy to repositioning maneuver did not show superiority to treatment with repositioning maneuvers alone. |
| first_indexed | 2024-04-10T13:57:51Z |
| format | Article |
| id | doaj.art-960d675c314c404599334f3fdcf4f8c2 |
| institution | Directory Open Access Journal |
| issn | 2667-7474 |
| language | English |
| last_indexed | 2024-04-10T13:57:51Z |
| publishDate | 2019-12-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Turkish Archives of Otorhinolaryngology |
| spelling | doaj.art-960d675c314c404599334f3fdcf4f8c22023-02-15T16:10:25ZengGalenos YayincilikTurkish Archives of Otorhinolaryngology2667-74742019-12-0157419119610.5152/tao.2019.418513049054An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional VertigoHakkı Caner İnan0Merve Kıraç1 Department of Otorhinolaryngology, Erzincan University School of Medicine, Erzincan, Turkey Department of Otorhinolaryngology, Erzincan University School of Medicine, Erzincan, Turkey Objective:Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular system disease causing dizziness. It occurs more in the 5th decade of life and affects the posterior canal in 90% of the patients. The most effective treatment method is canalith repositioning (CRP) maneuver. The aim of this study is to evaluate the effects of betahistine and dimenhydrinate therapies in addition to CRP maneuver on BPPV patients.Methods:The study included 64 patients who had complaints of dizziness and were diagnosed with BPPV by their history and provocation maneuvers. The patients were divided into two groups. In Group 1, only repositioning maneuver was performed. Group 2 was divided into two subgroups. In Group 2a, repositioning maneuver was performed and betahistine 24 mg twice daily was given for 10 days. In Group 2b, repositioning maneuver was performed and dimenhydrinate 50 mg once daily was given for five days. On the 10th day, all patients were reexamined, and provocation maneuver was performed. Dizziness handicap inventory (DHI) was completed and outcomes were reviewed for therapeutic efficacy.Results:Mean DHI scores in all patient groups statistically significantly decreased from a pre-treatment level of 52.16 (range, 20-100) to a post-treatment level of 17.84 (range, 0-78) (p<0.001). No statistically significant differences were found in terms of DHI scores between Group 1 (repositioning maneuver only) and Group 2 (repositioning maneuver plus betahistine or dimenhydrinate).Conclusion:The most effective treatment method of BPPV is repositioning maneuver. Addition of betahistine or dimenhydrinate pharmacotherapy to repositioning maneuver did not show superiority to treatment with repositioning maneuvers alone. http://turkarchotolaryngol.net/archives/archive-detail/article-preview/an-evaluation-of-the-effects-of-betahistine-and-di/43069 benign paroxysmal positional vertigocanalith repositioning maneuverpharmacotherapyepley maneuver |
| spellingShingle | Hakkı Caner İnan Merve Kıraç An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo Turkish Archives of Otorhinolaryngology benign paroxysmal positional vertigo canalith repositioning maneuver pharmacotherapy epley maneuver |
| title | An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo |
| title_full | An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo |
| title_fullStr | An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo |
| title_full_unstemmed | An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo |
| title_short | An Evaluation of the Effects of Betahistine and Dimenhydrinate on Posterior Canal Benign Paroxysmal Positional Vertigo |
| title_sort | evaluation of the effects of betahistine and dimenhydrinate on posterior canal benign paroxysmal positional vertigo |
| topic | benign paroxysmal positional vertigo canalith repositioning maneuver pharmacotherapy epley maneuver |
| url |
http://turkarchotolaryngol.net/archives/archive-detail/article-preview/an-evaluation-of-the-effects-of-betahistine-and-di/43069
|
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