Cardiotonic properties of high density lipoproteins
The ability of rat plasma high density lipoproteins (HDLs) to increase the frequency and amplitude of isolated rat heart contraction without considerable increase of oxygen consumption was revealed in Langendorf model. 30 min perfusion of solution with adrenalin in the regime of recirculation dimini...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2013-06-01
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| Series: | Атеросклероз |
| Subjects: | |
| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/671/609 |
| _version_ | 1828073460208762880 |
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| author | L. E. Panin A. R. Kolpakov R. A. Knyazev N. I. Tsirelnikov |
| author_facet | L. E. Panin A. R. Kolpakov R. A. Knyazev N. I. Tsirelnikov |
| author_sort | L. E. Panin |
| collection | DOAJ |
| description | The ability of rat plasma high density lipoproteins (HDLs) to increase the frequency and amplitude of isolated rat heart contraction without considerable increase of oxygen consumption was revealed in Langendorf model. 30 min perfusion of solution with adrenalin in the regime of recirculation diminished the contractility of myocardium and increased heart oxygen consumption. The addition of HDLs in the perfusion solution protected the heart from the negative adrenalin action. The established inotropic effects of HDLs may have various mechanisms and make high density lipoproteins pоssible candidates for the endogenous digitalis-like compounds. |
| first_indexed | 2024-04-11T01:29:30Z |
| format | Article |
| id | doaj.art-960f2e54af504d7ab5a104518a25a29d |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T01:29:30Z |
| publishDate | 2013-06-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-960f2e54af504d7ab5a104518a25a29d2023-01-03T10:04:00ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2013-06-0192510Cardiotonic properties of high density lipoproteinsL. E. Panin0A. R. Kolpakov1R. A. Knyazev2N. I. Tsirelnikov3RAMS Russian Federation SB RAMS Federal State Budgetary Institution "Research Institute of Biochemistry"RAMS Russian Federation SB RAMS Federal State Budgetary Institution "Research Institute of Biochemistry"RAMS Russian Federation SB RAMS Federal State Budgetary Institution "Research Institute of Biochemistry"RAMS Russian Federation SB RAMS Federal State Budgetary Institution "Research Institute of Biochemistry"The ability of rat plasma high density lipoproteins (HDLs) to increase the frequency and amplitude of isolated rat heart contraction without considerable increase of oxygen consumption was revealed in Langendorf model. 30 min perfusion of solution with adrenalin in the regime of recirculation diminished the contractility of myocardium and increased heart oxygen consumption. The addition of HDLs in the perfusion solution protected the heart from the negative adrenalin action. The established inotropic effects of HDLs may have various mechanisms and make high density lipoproteins pоssible candidates for the endogenous digitalis-like compounds.https://ateroskleroz.elpub.ru/jour/article/view/671/609isolated rat hearthigh density lipoproteinsadrenalincardiotonic actiondigitalis |
| spellingShingle | L. E. Panin A. R. Kolpakov R. A. Knyazev N. I. Tsirelnikov Cardiotonic properties of high density lipoproteins Атеросклероз isolated rat heart high density lipoproteins adrenalin cardiotonic action digitalis |
| title | Cardiotonic properties of high density lipoproteins |
| title_full | Cardiotonic properties of high density lipoproteins |
| title_fullStr | Cardiotonic properties of high density lipoproteins |
| title_full_unstemmed | Cardiotonic properties of high density lipoproteins |
| title_short | Cardiotonic properties of high density lipoproteins |
| title_sort | cardiotonic properties of high density lipoproteins |
| topic | isolated rat heart high density lipoproteins adrenalin cardiotonic action digitalis |
| url | https://ateroskleroz.elpub.ru/jour/article/view/671/609 |
| work_keys_str_mv | AT lepanin cardiotonicpropertiesofhighdensitylipoproteins AT arkolpakov cardiotonicpropertiesofhighdensitylipoproteins AT raknyazev cardiotonicpropertiesofhighdensitylipoproteins AT nitsirelnikov cardiotonicpropertiesofhighdensitylipoproteins |