Phytocannabinoids in the Pharmacotherapy of Psoriasis
Phytocannabinoids are naturally occurring compounds, the main source of which is <i>Cannabis sativa</i> L. Through direct action or interaction with G protein-coupled receptors, they affect ROS and pro-inflammatory cytokines levels and modify the effectiveness of transcription factor res...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/3/1192 |
| _version_ | 1827759861906014208 |
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| author | Adam Wroński Iwona Jarocka-Karpowicz Anna Stasiewicz Elżbieta Skrzydlewska |
| author_facet | Adam Wroński Iwona Jarocka-Karpowicz Anna Stasiewicz Elżbieta Skrzydlewska |
| author_sort | Adam Wroński |
| collection | DOAJ |
| description | Phytocannabinoids are naturally occurring compounds, the main source of which is <i>Cannabis sativa</i> L. Through direct action or interaction with G protein-coupled receptors, they affect ROS and pro-inflammatory cytokines levels and modify the effectiveness of transcription factor responsible for the biosynthesis of antioxidants which lead to oxidative stress and its consequences. Due to the modification of the redox balance and inflammation, phytocannabinoids are used in the treatment of various diseases, including autoimmune dermatoses, such as atopic dermatitis and psoriasis. Psoriasis is one of the most common dermatoses, and one of unknown etiology. A disturbed redox balance with a shift towards the oxidation leads to oxidative stress, resulting in oxidative modifications, mainly of lipids and proteins, and prolonged activation of immune cells and increased generation of pro-inflammatory cytokines, resulting in chronic inflammation. Given the biological activity of phytocannabinoids, they have become the focus of research as components of pharmacotherapy for psoriasis. Beneficial effects were shown by various representatives of phytocannabinoids, but the effect of cannabidiol (CBD) on skin cells (in vitro and ex vivo) and on blood cells from patients with psoriasis vulgaris and psoriatic arthritis has been most often evaluated in recent years. |
| first_indexed | 2024-03-11T09:33:33Z |
| format | Article |
| id | doaj.art-9611315031024610940f26f30472990b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T09:33:33Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9611315031024610940f26f30472990b2023-11-16T17:28:56ZengMDPI AGMolecules1420-30492023-01-01283119210.3390/molecules28031192Phytocannabinoids in the Pharmacotherapy of PsoriasisAdam Wroński0Iwona Jarocka-Karpowicz1Anna Stasiewicz2Elżbieta Skrzydlewska3Dermatological Specialized Center “DERMAL” NZOZ in Bialystok, 15-453 Bialystok, PolandDepartment of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, PolandDepartment of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, PolandDepartment of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, PolandPhytocannabinoids are naturally occurring compounds, the main source of which is <i>Cannabis sativa</i> L. Through direct action or interaction with G protein-coupled receptors, they affect ROS and pro-inflammatory cytokines levels and modify the effectiveness of transcription factor responsible for the biosynthesis of antioxidants which lead to oxidative stress and its consequences. Due to the modification of the redox balance and inflammation, phytocannabinoids are used in the treatment of various diseases, including autoimmune dermatoses, such as atopic dermatitis and psoriasis. Psoriasis is one of the most common dermatoses, and one of unknown etiology. A disturbed redox balance with a shift towards the oxidation leads to oxidative stress, resulting in oxidative modifications, mainly of lipids and proteins, and prolonged activation of immune cells and increased generation of pro-inflammatory cytokines, resulting in chronic inflammation. Given the biological activity of phytocannabinoids, they have become the focus of research as components of pharmacotherapy for psoriasis. Beneficial effects were shown by various representatives of phytocannabinoids, but the effect of cannabidiol (CBD) on skin cells (in vitro and ex vivo) and on blood cells from patients with psoriasis vulgaris and psoriatic arthritis has been most often evaluated in recent years.https://www.mdpi.com/1420-3049/28/3/1192phytocannabinoidsCBDpsoriasisoxidative stressinflammationskin cells |
| spellingShingle | Adam Wroński Iwona Jarocka-Karpowicz Anna Stasiewicz Elżbieta Skrzydlewska Phytocannabinoids in the Pharmacotherapy of Psoriasis Molecules phytocannabinoids CBD psoriasis oxidative stress inflammation skin cells |
| title | Phytocannabinoids in the Pharmacotherapy of Psoriasis |
| title_full | Phytocannabinoids in the Pharmacotherapy of Psoriasis |
| title_fullStr | Phytocannabinoids in the Pharmacotherapy of Psoriasis |
| title_full_unstemmed | Phytocannabinoids in the Pharmacotherapy of Psoriasis |
| title_short | Phytocannabinoids in the Pharmacotherapy of Psoriasis |
| title_sort | phytocannabinoids in the pharmacotherapy of psoriasis |
| topic | phytocannabinoids CBD psoriasis oxidative stress inflammation skin cells |
| url | https://www.mdpi.com/1420-3049/28/3/1192 |
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