In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity

In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity

The substrate-analog furin inhibitor MI-1851 can suppress the cleavage of SARS-CoV-2 spike protein and consequently produces significant antiviral effect on infected human airway epithelial cells. In this study, the interaction of inhibitor MI-1851 was examined with human serum albumin using fluores...

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Bibliographic Details
Main Authors: Erzsébet Pászti-Gere, Anna Szentkirályi-Tóth, Pál Szabó, Torsten Steinmetzer, Eszter Fliszár-Nyúl, Miklós Poór
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
MI-1851
Furin inhibitor
Primary human hepatocytes
CYP3A4
Human serum albumin
Cell viability
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222005133

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