An Anti-Cancer Peptide LVTX-8 Inhibits the Proliferation and Migration of Lung Tumor Cells by Regulating Causal Genes’ Expression in p53-Related Pathways

An Anti-Cancer Peptide LVTX-8 Inhibits the Proliferation and Migration of Lung Tumor Cells by Regulating Causal Genes’ Expression in p53-Related Pathways

Spider venom has been found to show its anticancer activity in a variety of human malignancies, including lung cancer. In this study, we investigated the anti-cancer peptide toxin LVTX-8, with linear amphipathic alpha-helical conformation, designed and synthesized from the <i>c</i>DNA li...

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Bibliographic Details
Main Authors: Peng Zhang, Yujie Yan, Junting Wang, Xiaoping Dong, Gaihua Zhang, Yong Zeng, Zhonghua Liu
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Toxins
Subjects:
peptide
LVTX-8
cytotoxicity
migration
transcriptomics
nude mouse model
Online Access:https://www.mdpi.com/2072-6651/12/6/367

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