Can direct smear results that are routinely collected at health centre level be used for monitoring the impact of mass drug administration with praziquantel on schistosomiasis in Burundi? A preliminary assessment
Abstract Background Intestinal schistosomiasis is still a public health problem in Burundi. Since 2008, annual mass drug administration with praziquantel has been rolled out in 11 endemic districts. The national programme relies on school-based surveys with kato-katz to monitor the impact of mass dr...
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | Parasites & Vectors |
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| Online Access: | http://link.springer.com/article/10.1186/s13071-020-04076-4 |
| _version_ | 1819133698624192512 |
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| author | Paul Bizimana Katja Polman Giuseppina Ortu Meryam Krit Frédéric Nsabiyumva Audace Nkeshimana Urlich Bijabuka Marcelline Nibakire Jean-Pierre Van Geertruyden |
| author_facet | Paul Bizimana Katja Polman Giuseppina Ortu Meryam Krit Frédéric Nsabiyumva Audace Nkeshimana Urlich Bijabuka Marcelline Nibakire Jean-Pierre Van Geertruyden |
| author_sort | Paul Bizimana |
| collection | DOAJ |
| description | Abstract Background Intestinal schistosomiasis is still a public health problem in Burundi. Since 2008, annual mass drug administration with praziquantel has been rolled out in 11 endemic districts. The national programme relies on school-based surveys with kato-katz to monitor the impact of mass drug administration. We explored whether routine data on intestinal schistosomiasis as determined by direct fecal smears at health centre level could be used. Methods From the Burundian National Health Information System, we collected routine incidence data on intestinal schistosomiasis as determined by direct smear examination in all 45 sanitary districts during 2011–2015. A temporal trends analysis was performed using a mixed negative binomial regression. Sanitary districts with mass drug administration campaigns with praziquantel (n = 11) were compared with those without (n = 34). In addition, prevalence data on intestinal schistosomiasis based on kato-katz results from a school-based national mapping in 2014 were compared with the incidence data in health centres based on direct smear results, in the same 45 sanitary districts. Results In the 11 sanitary districts applying mass drug administration with praziquantel, the incidence rate decreased significantly for the years 2014 (β 2014 = − 0.826, P = 0.010) and 2015 (β 2015 = − 1.294, P < 0.001) and for the five-year period (β = − 0.286, P < 0.001), whereas in the 34 districts where mass drug administration was not delivered, there was no significant decrease over time (β = − 0.087, P = 0.219). In most of the 45 sanitary districts, the low prevalence based on kato-katz in school children was confirmed by low incidence rates based on direct smears in the health centres. Conclusions National Health Information System surveillance data, based on routinely collected direct smear results at health centre level, may be able to monitor the impact of mass drug administration with praziquantel on intestinal schistosomiasis in Burundi. Control and elimination of intestinal schistosomiasis call for integration of adequate diagnosis and treatment into routine activities of primary health care facilities, as recommended by the World Health Organization since more than 20 years. When moving towards elimination, more sensitive tests, such as the point-of-care circulating cathodic antigen assay are desirable. |
| first_indexed | 2024-12-22T09:51:26Z |
| format | Article |
| id | doaj.art-9611ead259214408a057ace34a02b388 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-22T09:51:26Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-9611ead259214408a057ace34a02b3882022-12-21T18:30:22ZengBMCParasites & Vectors1756-33052020-04-011311710.1186/s13071-020-04076-4Can direct smear results that are routinely collected at health centre level be used for monitoring the impact of mass drug administration with praziquantel on schistosomiasis in Burundi? A preliminary assessmentPaul Bizimana0Katja Polman1Giuseppina Ortu2Meryam Krit3Frédéric Nsabiyumva4Audace Nkeshimana5Urlich Bijabuka6Marcelline Nibakire7Jean-Pierre Van Geertruyden8Global Health Institute, Department of Epidemiology and Social Medicine, Faculty of Medicine and Health Sciences, University of AntwerpMedical Helminthology Unit, Department of Biomedical Sciences, Institute of Tropical MedicineGlobal Health ConsultantBiostatistics and Epidemiology Unit, Department of Biomedical Sciences, Institute of Tropical MedicineDépartement de Médecine Interne, Faculté de Médecine de Bujumbura, Université du BurundiDépartement des Sciences de la Santé Publique, Direction de la Formation, Institut National de Santé PubliqueDépartement des Sciences de la Santé Publique, Institut Universitaire des Sciences de la Santé et de Développement CommunautaireBureau de la Municipalité Sanitaire de Bujumbura, Ministère de la Santé Publique et de la Lutte contre le SidaGlobal Health Institute, Department of Epidemiology and Social Medicine, Faculty of Medicine and Health Sciences, University of AntwerpAbstract Background Intestinal schistosomiasis is still a public health problem in Burundi. Since 2008, annual mass drug administration with praziquantel has been rolled out in 11 endemic districts. The national programme relies on school-based surveys with kato-katz to monitor the impact of mass drug administration. We explored whether routine data on intestinal schistosomiasis as determined by direct fecal smears at health centre level could be used. Methods From the Burundian National Health Information System, we collected routine incidence data on intestinal schistosomiasis as determined by direct smear examination in all 45 sanitary districts during 2011–2015. A temporal trends analysis was performed using a mixed negative binomial regression. Sanitary districts with mass drug administration campaigns with praziquantel (n = 11) were compared with those without (n = 34). In addition, prevalence data on intestinal schistosomiasis based on kato-katz results from a school-based national mapping in 2014 were compared with the incidence data in health centres based on direct smear results, in the same 45 sanitary districts. Results In the 11 sanitary districts applying mass drug administration with praziquantel, the incidence rate decreased significantly for the years 2014 (β 2014 = − 0.826, P = 0.010) and 2015 (β 2015 = − 1.294, P < 0.001) and for the five-year period (β = − 0.286, P < 0.001), whereas in the 34 districts where mass drug administration was not delivered, there was no significant decrease over time (β = − 0.087, P = 0.219). In most of the 45 sanitary districts, the low prevalence based on kato-katz in school children was confirmed by low incidence rates based on direct smears in the health centres. Conclusions National Health Information System surveillance data, based on routinely collected direct smear results at health centre level, may be able to monitor the impact of mass drug administration with praziquantel on intestinal schistosomiasis in Burundi. Control and elimination of intestinal schistosomiasis call for integration of adequate diagnosis and treatment into routine activities of primary health care facilities, as recommended by the World Health Organization since more than 20 years. When moving towards elimination, more sensitive tests, such as the point-of-care circulating cathodic antigen assay are desirable.http://link.springer.com/article/10.1186/s13071-020-04076-4BurundiDirect smearHealth centreMass drug administrationMonitoringRoutine data |
| spellingShingle | Paul Bizimana Katja Polman Giuseppina Ortu Meryam Krit Frédéric Nsabiyumva Audace Nkeshimana Urlich Bijabuka Marcelline Nibakire Jean-Pierre Van Geertruyden Can direct smear results that are routinely collected at health centre level be used for monitoring the impact of mass drug administration with praziquantel on schistosomiasis in Burundi? A preliminary assessment Parasites & Vectors Burundi Direct smear Health centre Mass drug administration Monitoring Routine data |
| title | Can direct smear results that are routinely collected at health centre level be used for monitoring the impact of mass drug administration with praziquantel on schistosomiasis in Burundi? A preliminary assessment |
| title_full | Can direct smear results that are routinely collected at health centre level be used for monitoring the impact of mass drug administration with praziquantel on schistosomiasis in Burundi? A preliminary assessment |
| title_fullStr | Can direct smear results that are routinely collected at health centre level be used for monitoring the impact of mass drug administration with praziquantel on schistosomiasis in Burundi? A preliminary assessment |
| title_full_unstemmed | Can direct smear results that are routinely collected at health centre level be used for monitoring the impact of mass drug administration with praziquantel on schistosomiasis in Burundi? A preliminary assessment |
| title_short | Can direct smear results that are routinely collected at health centre level be used for monitoring the impact of mass drug administration with praziquantel on schistosomiasis in Burundi? A preliminary assessment |
| title_sort | can direct smear results that are routinely collected at health centre level be used for monitoring the impact of mass drug administration with praziquantel on schistosomiasis in burundi a preliminary assessment |
| topic | Burundi Direct smear Health centre Mass drug administration Monitoring Routine data |
| url | http://link.springer.com/article/10.1186/s13071-020-04076-4 |
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