Immune Pressure on Polymorphous Influenza B Populations Results in Diverse Hemagglutinin Escape Mutants and Lineage Switching

Immune Pressure on Polymorphous Influenza B Populations Results in Diverse Hemagglutinin Escape Mutants and Lineage Switching

Mutations arise in the genomes of progeny viruses during infection. Mutations that occur in epitopes targeted by host antibodies allow the progeny virus to escape the host adaptive, B-cell mediated antibody immune response. Major epitopes have been identified in influenza B virus (IBV) hemagglutinin...

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Bibliographic Details
Main Authors: Ewan P. Plant, Hasmik Manukyan, Jose L. Sanchez, Majid Laassri, Zhiping Ye
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Vaccines
Subjects:
influenza b
hemagglutinin
lineage
quasispecies
next generation sequencing
Online Access:https://www.mdpi.com/2076-393X/8/1/125

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