Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action
<i>Lactiplantibacillus plantarum</i> (<i>L. plantarum</i>) is a well-studied and versatile species of lactobacilli. It is found in several niches, including human mucosal surfaces, and it is largely employed in the food industry and boasts a millenary tradition of safe use, s...
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/12076 |
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| author | Maria Teresa Rocchetti Pasquale Russo Vittorio Capozzi Djamel Drider Giuseppe Spano Daniela Fiocco |
| author_facet | Maria Teresa Rocchetti Pasquale Russo Vittorio Capozzi Djamel Drider Giuseppe Spano Daniela Fiocco |
| author_sort | Maria Teresa Rocchetti |
| collection | DOAJ |
| description | <i>Lactiplantibacillus plantarum</i> (<i>L. plantarum</i>) is a well-studied and versatile species of lactobacilli. It is found in several niches, including human mucosal surfaces, and it is largely employed in the food industry and boasts a millenary tradition of safe use, sharing a long-lasting relationship with humans. <i>L. plantarum</i> is generally recognised as safe and exhibits a strong probiotic character, so that several strains are commercialised as health-promoting supplements and functional food products. For these reasons, <i>L. plantarum</i> represents a valuable model to gain insight into the nature and mechanisms of antimicrobials as key factors underlying the probiotic action of health-promoting microbes. Probiotic antimicrobials can inhibit the growth of pathogens in the gut ensuring the intestinal homeostasis and contributing to the host health. Furthermore, they may be attractive alternatives to conventional antibiotics, holding potential in several biomedical applications. The aim of this review is to investigate the most relevant papers published in the last ten years, bioprospecting the antimicrobial activity of characterised probiotic <i>L. plantarum</i> strains. Specifically, it focuses on the different chemical nature, the action spectra and the mechanisms underlying the bioactivity of their antibacterial and antiviral agents. Emerging trends in postbiotics, some in vivo applications of <i>L. plantarum</i> antimicrobials, including strengths and limitations of their therapeutic potential, are addressed and discussed. |
| first_indexed | 2024-03-10T05:59:55Z |
| format | Article |
| id | doaj.art-9612c95f4678461aa9870af36e11eacc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:59:55Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9612c95f4678461aa9870af36e11eacc2023-11-22T21:02:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122211207610.3390/ijms222112076Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic ActionMaria Teresa Rocchetti0Pasquale Russo1Vittorio Capozzi2Djamel Drider3Giuseppe Spano4Daniela Fiocco5Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Agriculture Food Natural Science Engineering (DAFNE), University of Foggia, 71122 Foggia, ItalyInstitute of Sciences of Food Production, National Research Council (CNR) of Italy, c/o CS-DAT, Via Michele Protano, 71122 Foggia, ItalyUMR Transfrontalière BioEcoAgro1158, Univ. Lille, INRAE, Univ. Liège, UPJV, YNCREA, Univ. Artois, Univ. Littoral Côte d’Opale, ICV-Institut Charles Viollette, F-59000 Lille, FranceDepartment of Agriculture Food Natural Science Engineering (DAFNE), University of Foggia, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy<i>Lactiplantibacillus plantarum</i> (<i>L. plantarum</i>) is a well-studied and versatile species of lactobacilli. It is found in several niches, including human mucosal surfaces, and it is largely employed in the food industry and boasts a millenary tradition of safe use, sharing a long-lasting relationship with humans. <i>L. plantarum</i> is generally recognised as safe and exhibits a strong probiotic character, so that several strains are commercialised as health-promoting supplements and functional food products. For these reasons, <i>L. plantarum</i> represents a valuable model to gain insight into the nature and mechanisms of antimicrobials as key factors underlying the probiotic action of health-promoting microbes. Probiotic antimicrobials can inhibit the growth of pathogens in the gut ensuring the intestinal homeostasis and contributing to the host health. Furthermore, they may be attractive alternatives to conventional antibiotics, holding potential in several biomedical applications. The aim of this review is to investigate the most relevant papers published in the last ten years, bioprospecting the antimicrobial activity of characterised probiotic <i>L. plantarum</i> strains. Specifically, it focuses on the different chemical nature, the action spectra and the mechanisms underlying the bioactivity of their antibacterial and antiviral agents. Emerging trends in postbiotics, some in vivo applications of <i>L. plantarum</i> antimicrobials, including strengths and limitations of their therapeutic potential, are addressed and discussed.https://www.mdpi.com/1422-0067/22/21/12076<i>Lactiplantibacillus plantarum</i>lactic acid bacteriaprobioticsantibacterial extracellular compoundantiviral extracellular compoundprobiosis |
| spellingShingle | Maria Teresa Rocchetti Pasquale Russo Vittorio Capozzi Djamel Drider Giuseppe Spano Daniela Fiocco Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action International Journal of Molecular Sciences <i>Lactiplantibacillus plantarum</i> lactic acid bacteria probiotics antibacterial extracellular compound antiviral extracellular compound probiosis |
| title | Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action |
| title_full | Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action |
| title_fullStr | Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action |
| title_full_unstemmed | Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action |
| title_short | Bioprospecting Antimicrobials from <i>Lactiplantibacillus plantarum</i>: Key Factors Underlying Its Probiotic Action |
| title_sort | bioprospecting antimicrobials from i lactiplantibacillus plantarum i key factors underlying its probiotic action |
| topic | <i>Lactiplantibacillus plantarum</i> lactic acid bacteria probiotics antibacterial extracellular compound antiviral extracellular compound probiosis |
| url | https://www.mdpi.com/1422-0067/22/21/12076 |
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