Crosstalk of Exosomal Non-Coding RNAs in The Tumor Microenvironment: Novel Frontiers
The tumor microenvironment (TME) is defined as a complex and dynamic tissue entity composed of endothelial, stromal, immune cells, and the blood system. The homeostasis and evolution of the TME are governed by intimate interactions among cellular compartments. The malignant behavior of cancer cells,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.900155/full |
| _version_ | 1818530109199482880 |
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| author | Zimo Jia Zimo Jia Jinlin Jia Jinlin Jia Lihui Yao Zhihan Li |
| author_facet | Zimo Jia Zimo Jia Jinlin Jia Jinlin Jia Lihui Yao Zhihan Li |
| author_sort | Zimo Jia |
| collection | DOAJ |
| description | The tumor microenvironment (TME) is defined as a complex and dynamic tissue entity composed of endothelial, stromal, immune cells, and the blood system. The homeostasis and evolution of the TME are governed by intimate interactions among cellular compartments. The malignant behavior of cancer cells, such as infiltrating growth, proliferation, invasion, and metastasis, is predominantly dependent on the bidirectional communication between tumor cells and the TME. And such dialogue mainly involves the transfer of multifunctional regulatory molecules from tumor cells and/or stromal cells within the TME. Interestingly, increasing evidence has confirmed that exosomes carrying regulatory molecules, proteins, and nucleic acids act as an active link in cellular crosstalk in the TME. Notably, extensive studies have identified non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), that could be encapsulated by exosomes, which regulate the coordinated function within the TME and thus participate in cancer development and progression. In this review, we summarize recent literature around the topic of the functions and mechanisms of exosomal ncRNAs in the TME and highlight their clinical significance. |
| first_indexed | 2024-12-11T17:15:35Z |
| format | Article |
| id | doaj.art-96136486c45e43ad8725c8ce51ee9f4c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T17:15:35Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-96136486c45e43ad8725c8ce51ee9f4c2022-12-22T00:57:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.900155900155Crosstalk of Exosomal Non-Coding RNAs in The Tumor Microenvironment: Novel FrontiersZimo Jia0Zimo Jia1Jinlin Jia2Jinlin Jia3Lihui Yao4Zhihan Li5Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, ChinaThe Second General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaNational Research Institute for Family Planning, National Human Genetic Resources Center, Beijing, ChinaGraduate School, Peking Union Medical College, Beijing, ChinaDepartment of Otolaryngology, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, ChinaThe Second General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaThe tumor microenvironment (TME) is defined as a complex and dynamic tissue entity composed of endothelial, stromal, immune cells, and the blood system. The homeostasis and evolution of the TME are governed by intimate interactions among cellular compartments. The malignant behavior of cancer cells, such as infiltrating growth, proliferation, invasion, and metastasis, is predominantly dependent on the bidirectional communication between tumor cells and the TME. And such dialogue mainly involves the transfer of multifunctional regulatory molecules from tumor cells and/or stromal cells within the TME. Interestingly, increasing evidence has confirmed that exosomes carrying regulatory molecules, proteins, and nucleic acids act as an active link in cellular crosstalk in the TME. Notably, extensive studies have identified non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), that could be encapsulated by exosomes, which regulate the coordinated function within the TME and thus participate in cancer development and progression. In this review, we summarize recent literature around the topic of the functions and mechanisms of exosomal ncRNAs in the TME and highlight their clinical significance.https://www.frontiersin.org/articles/10.3389/fimmu.2022.900155/fullexosomestumor microenvironmentnon-coding RNAstumor immunitycancer |
| spellingShingle | Zimo Jia Zimo Jia Jinlin Jia Jinlin Jia Lihui Yao Zhihan Li Crosstalk of Exosomal Non-Coding RNAs in The Tumor Microenvironment: Novel Frontiers Frontiers in Immunology exosomes tumor microenvironment non-coding RNAs tumor immunity cancer |
| title | Crosstalk of Exosomal Non-Coding RNAs in The Tumor Microenvironment: Novel Frontiers |
| title_full | Crosstalk of Exosomal Non-Coding RNAs in The Tumor Microenvironment: Novel Frontiers |
| title_fullStr | Crosstalk of Exosomal Non-Coding RNAs in The Tumor Microenvironment: Novel Frontiers |
| title_full_unstemmed | Crosstalk of Exosomal Non-Coding RNAs in The Tumor Microenvironment: Novel Frontiers |
| title_short | Crosstalk of Exosomal Non-Coding RNAs in The Tumor Microenvironment: Novel Frontiers |
| title_sort | crosstalk of exosomal non coding rnas in the tumor microenvironment novel frontiers |
| topic | exosomes tumor microenvironment non-coding RNAs tumor immunity cancer |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.900155/full |
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