Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report
Abstract Background Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy. However, acromegaly is a disease that causes peculiar facial fe...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-09-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13256-019-2228-z |
| _version_ | 1818575634710921216 |
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| author | Arina Yamasaki Daisuke Bito Erina Eto Keiichiro Matsumoto Megumi Nakamura Junji Miyazaki Kenichi Matsumoto Masanori Masuda Daisuke Mori Toru Yoshimura |
| author_facet | Arina Yamasaki Daisuke Bito Erina Eto Keiichiro Matsumoto Megumi Nakamura Junji Miyazaki Kenichi Matsumoto Masanori Masuda Daisuke Mori Toru Yoshimura |
| author_sort | Arina Yamasaki |
| collection | DOAJ |
| description | Abstract Background Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy. However, acromegaly is a disease that causes peculiar facial features, body types, and metabolic abnormalities due to the excessive secretion of growth hormone by a pituitary adenoma. Growth hormone has been reported to be involved in glomerular cell growth, mesangial proliferation, and glomerulosclerosis in the kidney. Case presentation We report a case of a Japanese patient with focal segmental glomerulosclerosis in whom decreased urinary protein was observed after surgical treatment for acromegaly. Conclusion The patient’s urinary protein improved as the concentration of growth hormone/insulin-like growth factor 1 decreased. |
| first_indexed | 2024-12-15T00:43:35Z |
| format | Article |
| id | doaj.art-9614e9eb3ea64dea9449d21c86e8619d |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-15T00:43:35Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-9614e9eb3ea64dea9449d21c86e8619d2022-12-21T22:41:35ZengBMCJournal of Medical Case Reports1752-19472019-09-011311610.1186/s13256-019-2228-zFocal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case reportArina Yamasaki0Daisuke Bito1Erina Eto2Keiichiro Matsumoto3Megumi Nakamura4Junji Miyazaki5Kenichi Matsumoto6Masanori Masuda7Daisuke Mori8Toru Yoshimura9Diabetes and Endocrinology, Saga-Ken Medical Centre KoseikanDiabetes and Endocrinology, Saga-Ken Medical Centre KoseikanDiabetes and Endocrinology, Saga-Ken Medical Centre KoseikanNephrology, Saga-Ken Medical Centre KoseikanNephrology, Saga-Ken Medical Centre KoseikanOtorhinolaryngology, Saga-Ken Medical Centre KoseikanNeurosurgery, Saga-Ken Medical Centre KoseikanDiagnostic Pathology, Saga-Ken Medical Centre KoseikanDiagnostic Pathology, Saga-Ken Medical Centre KoseikanDiabetes and Endocrinology, Saga-Ken Medical Centre KoseikanAbstract Background Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy. However, acromegaly is a disease that causes peculiar facial features, body types, and metabolic abnormalities due to the excessive secretion of growth hormone by a pituitary adenoma. Growth hormone has been reported to be involved in glomerular cell growth, mesangial proliferation, and glomerulosclerosis in the kidney. Case presentation We report a case of a Japanese patient with focal segmental glomerulosclerosis in whom decreased urinary protein was observed after surgical treatment for acromegaly. Conclusion The patient’s urinary protein improved as the concentration of growth hormone/insulin-like growth factor 1 decreased.http://link.springer.com/article/10.1186/s13256-019-2228-zAcromegalyFocal segmental glomerulosclerosisGrowth hormoneInsulin-like growth factor 1 |
| spellingShingle | Arina Yamasaki Daisuke Bito Erina Eto Keiichiro Matsumoto Megumi Nakamura Junji Miyazaki Kenichi Matsumoto Masanori Masuda Daisuke Mori Toru Yoshimura Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report Journal of Medical Case Reports Acromegaly Focal segmental glomerulosclerosis Growth hormone Insulin-like growth factor 1 |
| title | Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report |
| title_full | Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report |
| title_fullStr | Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report |
| title_full_unstemmed | Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report |
| title_short | Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report |
| title_sort | focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly a case report |
| topic | Acromegaly Focal segmental glomerulosclerosis Growth hormone Insulin-like growth factor 1 |
| url | http://link.springer.com/article/10.1186/s13256-019-2228-z |
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