Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model
Abstract Background The second most common cancer in the world is breast cancer. Chemotherapy is used to treat breast cancer, but instances of multidrug resistance, targets that are not selective, and physicochemical issues raise doubts about its efficacy. So, the exploration of chemopreventive agen...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | Bulletin of the National Research Centre |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42269-023-01161-3 |
| _version_ | 1797363679459540992 |
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| author | Aida I. El makawy Sekena H. Abdel-Aziem Shaimaa E. Mohammed Faten M. Ibrahim Heba A. Abd EL-Kader Hafiza A. Sharaf Dalia A. Youssef Dalia M. Mabrouk |
| author_facet | Aida I. El makawy Sekena H. Abdel-Aziem Shaimaa E. Mohammed Faten M. Ibrahim Heba A. Abd EL-Kader Hafiza A. Sharaf Dalia A. Youssef Dalia M. Mabrouk |
| author_sort | Aida I. El makawy |
| collection | DOAJ |
| description | Abstract Background The second most common cancer in the world is breast cancer. Chemotherapy is used to treat breast cancer, but instances of multidrug resistance, targets that are not selective, and physicochemical issues raise doubts about its efficacy. So, the exploration of chemopreventive agents from efficient natural sources has been required. The chia and quinoa seeds have health-promoting activities that include cardio-protective, antidiabetic, and anticancer effects. Given the paramount importance of their oils and their potential bioactivities, this work aimed to assess the repressive effect of their oil nanocapsules against mammary tumors in rats. Rat models of chemically induced mammary tumors were gavaged with chia and quinoa nanocapsules for one month. The repressive effect of nanocapsules was studied by quantifying TNF-α, assessing the gene expression of proto-oncogenes (PIK3CA and MYC) using qRT-PCR, and analyzing the cell cycle in mammary tissue. Results The studies clarified that the inhibition of tumors in response to quinoa and chia nanocapsules was associated with a reduction in TNF-α levels, proliferation capability, and motivation for apoptosis. Furthermore, quinoa and chia nanocapsule management repressed the activation of the MYC and PIK3CA genes. As well as nanocapsules modulated the liver enzymes and kidney function alterations induced in mammary tumor animals. Meanwhile, both oils' nanocapsules do not have an impact on the liver and kidneys of healthy rats. Conclusions The findings indicate that quinoa and chia nanocapsules are safe and can reduce tumor growth, suggesting a potential natural therapeutic target for breast cancer treatment. |
| first_indexed | 2024-03-08T16:24:27Z |
| format | Article |
| id | doaj.art-961650e49d034d949b248ac507dd76d0 |
| institution | Directory Open Access Journal |
| issn | 2522-8307 |
| language | English |
| last_indexed | 2024-03-08T16:24:27Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj.art-961650e49d034d949b248ac507dd76d02024-01-07T12:09:39ZengSpringerOpenBulletin of the National Research Centre2522-83072024-01-0148111510.1186/s42269-023-01161-3Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer modelAida I. El makawy0Sekena H. Abdel-Aziem1Shaimaa E. Mohammed2Faten M. Ibrahim3Heba A. Abd EL-Kader4Hafiza A. Sharaf5Dalia A. Youssef6Dalia M. Mabrouk7Cell Biology Department, Biotechnology Research Institute, National Research CentreCell Biology Department, Biotechnology Research Institute, National Research CentreFood Sciences and Nutrition Department, Food Industries and Nutrition Research Institute, National Research CentreMedicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Institute, National Research CentreCell Biology Department, Biotechnology Research Institute, National Research CentrePathology Department, Medicine and Clinical Studies Research Institute, National Research CentrePests and Plant Protection Department, Agricultural and Biology Research Institute, National Research CentreCell Biology Department, Biotechnology Research Institute, National Research CentreAbstract Background The second most common cancer in the world is breast cancer. Chemotherapy is used to treat breast cancer, but instances of multidrug resistance, targets that are not selective, and physicochemical issues raise doubts about its efficacy. So, the exploration of chemopreventive agents from efficient natural sources has been required. The chia and quinoa seeds have health-promoting activities that include cardio-protective, antidiabetic, and anticancer effects. Given the paramount importance of their oils and their potential bioactivities, this work aimed to assess the repressive effect of their oil nanocapsules against mammary tumors in rats. Rat models of chemically induced mammary tumors were gavaged with chia and quinoa nanocapsules for one month. The repressive effect of nanocapsules was studied by quantifying TNF-α, assessing the gene expression of proto-oncogenes (PIK3CA and MYC) using qRT-PCR, and analyzing the cell cycle in mammary tissue. Results The studies clarified that the inhibition of tumors in response to quinoa and chia nanocapsules was associated with a reduction in TNF-α levels, proliferation capability, and motivation for apoptosis. Furthermore, quinoa and chia nanocapsule management repressed the activation of the MYC and PIK3CA genes. As well as nanocapsules modulated the liver enzymes and kidney function alterations induced in mammary tumor animals. Meanwhile, both oils' nanocapsules do not have an impact on the liver and kidneys of healthy rats. Conclusions The findings indicate that quinoa and chia nanocapsules are safe and can reduce tumor growth, suggesting a potential natural therapeutic target for breast cancer treatment.https://doi.org/10.1186/s42269-023-01161-3NanoencapsulationAnti-inflammationProto-oncogenesCell proliferation |
| spellingShingle | Aida I. El makawy Sekena H. Abdel-Aziem Shaimaa E. Mohammed Faten M. Ibrahim Heba A. Abd EL-Kader Hafiza A. Sharaf Dalia A. Youssef Dalia M. Mabrouk Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model Bulletin of the National Research Centre Nanoencapsulation Anti-inflammation Proto-oncogenes Cell proliferation |
| title | Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model |
| title_full | Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model |
| title_fullStr | Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model |
| title_full_unstemmed | Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model |
| title_short | Exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of PIK3CA and MYC expression, anti-inflammation and cell proliferation inhibition, and their hepatorenal safety in rat breast cancer model |
| title_sort | exploration of tumor growth regression of quinoa and chia oil nanocapsules via the control of pik3ca and myc expression anti inflammation and cell proliferation inhibition and their hepatorenal safety in rat breast cancer model |
| topic | Nanoencapsulation Anti-inflammation Proto-oncogenes Cell proliferation |
| url | https://doi.org/10.1186/s42269-023-01161-3 |
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