Transmission and Demographic Dynamics of Coxsackievirus B1.
The infectious activity of coxsackievirus B1 (CV-B1) in Taiwan was high from 2008 to 2010, following an alarming increase in severe neonate disease in the United States (US). To examine the relationship between CV-B1 strains isolated in Taiwan and those from other parts of the world, we performed a...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4460132?pdf=render |
| _version_ | 1818948957496147968 |
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| author | Pei-Yu Chu Yu-Chang Tyan Yao-Shen Chen Hsiu-Lin Chen Po-Liang Lu Yu-Hsien Chen Bao-Chen Chen Tsi-Shu Huang Chu-Feng Wang Hui-Ju Su Yong-Ying Shi Bintou Sanno-Duanda Kuei-Hsiang Lin Kazushi Motomura |
| author_facet | Pei-Yu Chu Yu-Chang Tyan Yao-Shen Chen Hsiu-Lin Chen Po-Liang Lu Yu-Hsien Chen Bao-Chen Chen Tsi-Shu Huang Chu-Feng Wang Hui-Ju Su Yong-Ying Shi Bintou Sanno-Duanda Kuei-Hsiang Lin Kazushi Motomura |
| author_sort | Pei-Yu Chu |
| collection | DOAJ |
| description | The infectious activity of coxsackievirus B1 (CV-B1) in Taiwan was high from 2008 to 2010, following an alarming increase in severe neonate disease in the United States (US). To examine the relationship between CV-B1 strains isolated in Taiwan and those from other parts of the world, we performed a phylodynamic study using VP1 and partial 3Dpol (414 nt) sequences from 22 strains of CV-B1 isolated in Taiwan (1989-2010) and compared them to sequences from strains isolated worldwide. Phylogenetic trees were constructed by neighbor-joining, maximum likelihood, and Bayesian Monte Carlo Markov Chain methods. Four genotypes (GI-IV) in the VP1 region of CV-B1 and three genotypes (GA-C) in the 3Dpol region of enterovirus B were identified and had high support values. The phylogenetic analysis indicates that the GI and GIII strains in VP1 were geographically distributed in Taiwan (1993-1994) and in India (2007-2009). On the other hand, the GII and GIV strains appear to have a wider spatiotemporal distribution and ladder-like topology A stair-like phylogeny was observed in the VP1 region indicating that the phylogeny of the virus may be affected by different selection pressures in the specified regions. Further, most of the GI and GII strains in the VP1 tree were clustered together in GA in the 3D tree, while the GIV strains diverged into GB and GC. Taken together, these data provide important insights into the population dynamics of CV-B1 and indicate that incongruencies in specific gene regions may contribute to spatiotemporal patterns of epidemicity for this virus. |
| first_indexed | 2024-12-20T08:55:03Z |
| format | Article |
| id | doaj.art-961650f516ed4c92be607a2dd469683b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T08:55:03Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-961650f516ed4c92be607a2dd469683b2022-12-21T19:46:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012927210.1371/journal.pone.0129272Transmission and Demographic Dynamics of Coxsackievirus B1.Pei-Yu ChuYu-Chang TyanYao-Shen ChenHsiu-Lin ChenPo-Liang LuYu-Hsien ChenBao-Chen ChenTsi-Shu HuangChu-Feng WangHui-Ju SuYong-Ying ShiBintou Sanno-DuandaKuei-Hsiang LinKazushi MotomuraThe infectious activity of coxsackievirus B1 (CV-B1) in Taiwan was high from 2008 to 2010, following an alarming increase in severe neonate disease in the United States (US). To examine the relationship between CV-B1 strains isolated in Taiwan and those from other parts of the world, we performed a phylodynamic study using VP1 and partial 3Dpol (414 nt) sequences from 22 strains of CV-B1 isolated in Taiwan (1989-2010) and compared them to sequences from strains isolated worldwide. Phylogenetic trees were constructed by neighbor-joining, maximum likelihood, and Bayesian Monte Carlo Markov Chain methods. Four genotypes (GI-IV) in the VP1 region of CV-B1 and three genotypes (GA-C) in the 3Dpol region of enterovirus B were identified and had high support values. The phylogenetic analysis indicates that the GI and GIII strains in VP1 were geographically distributed in Taiwan (1993-1994) and in India (2007-2009). On the other hand, the GII and GIV strains appear to have a wider spatiotemporal distribution and ladder-like topology A stair-like phylogeny was observed in the VP1 region indicating that the phylogeny of the virus may be affected by different selection pressures in the specified regions. Further, most of the GI and GII strains in the VP1 tree were clustered together in GA in the 3D tree, while the GIV strains diverged into GB and GC. Taken together, these data provide important insights into the population dynamics of CV-B1 and indicate that incongruencies in specific gene regions may contribute to spatiotemporal patterns of epidemicity for this virus.http://europepmc.org/articles/PMC4460132?pdf=render |
| spellingShingle | Pei-Yu Chu Yu-Chang Tyan Yao-Shen Chen Hsiu-Lin Chen Po-Liang Lu Yu-Hsien Chen Bao-Chen Chen Tsi-Shu Huang Chu-Feng Wang Hui-Ju Su Yong-Ying Shi Bintou Sanno-Duanda Kuei-Hsiang Lin Kazushi Motomura Transmission and Demographic Dynamics of Coxsackievirus B1. PLoS ONE |
| title | Transmission and Demographic Dynamics of Coxsackievirus B1. |
| title_full | Transmission and Demographic Dynamics of Coxsackievirus B1. |
| title_fullStr | Transmission and Demographic Dynamics of Coxsackievirus B1. |
| title_full_unstemmed | Transmission and Demographic Dynamics of Coxsackievirus B1. |
| title_short | Transmission and Demographic Dynamics of Coxsackievirus B1. |
| title_sort | transmission and demographic dynamics of coxsackievirus b1 |
| url | http://europepmc.org/articles/PMC4460132?pdf=render |
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