S146: GENOMIC EVOLUTION AND RESISTANCE TO PIRTOBRUTINIB IN COVALENT BTK-INHIBITOR (CBTKI) PRE-TREATED CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) PATIENTS: RESULTS FROM THE PHASE I/II BRUIN STUDY - Jennifer R. Brown; Sai Prasad Desikan; Bastien Nguyen; Helen Won; Shady Tantawy; Samuel Clark Mcneely; Narasimha Marella; Kevin Ebata; Jennifer Woyach; Krish Patel; Constantine Tam; Toby Eyre; et al. (HemaSphere, 2023)