Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome
Background: Premature luteinization (PL) is defined as a premature rise in serum progesterone concentration on or before the day of ovulation trigger with human chorionic gonadotropin. The incidence of PL varies between 5% and 30% during in vitro fertilization and embryo transfer (IVF-ET). Materials...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=2;spage=136;epage=140;aulast=Nagaraja |
| _version_ | 1811208380365144064 |
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| author | N Nagaraja Pankaj Talwar Bhaskar Mukherjee Barun Kumar Chakrabarty |
| author_facet | N Nagaraja Pankaj Talwar Bhaskar Mukherjee Barun Kumar Chakrabarty |
| author_sort | N Nagaraja |
| collection | DOAJ |
| description | Background: Premature luteinization (PL) is defined as a premature rise in serum progesterone concentration on or before the day of ovulation trigger with human chorionic gonadotropin. The incidence of PL varies between 5% and 30% during in vitro fertilization and embryo transfer (IVF-ET). Materials and Methods: The prospective observational study comprising 380 patients undergoing IVF-ET. Blood samples were collected for serum progesterone level estimation on the day of ovulation trigger. Ovum pickup was done 36 h later and serum progesterone levels were correlated with IVF-ET outcome. Study Outcome: To correlate serum progesterone level on the day of ovulation trigger during IVF and its effect on treatment outcome. Results: Mean serum progesterone level in the positive pregnancy group and negative pregnancy group was 0.892 ± 0.752 ng/ml and 0.91 ± 0.688 ng/ml, respectively (P = 0.961). The overall incidence of PL was 12.8% with 12.7% and 13.6% in the agonist and antagonist protocol respectively (P = 0.9001). PL incidence was 13.5% and 13.4% in positive pregnancy and negative pregnancy group (P = 0.223). Conclusion: PL has been associated with 12.8% of the IVF cycles. There was no statistically significant difference observed in the incidence of PL between different IVF stimulation protocols. PL does not seem to affect IVF outcome. |
| first_indexed | 2024-04-12T04:20:15Z |
| format | Article |
| id | doaj.art-9618166603ef4b4185fc62aa1c592438 |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-04-12T04:20:15Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-9618166603ef4b4185fc62aa1c5924382022-12-22T03:48:15ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662019-01-0112213614010.4103/jhrs.JHRS_115_18Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcomeN NagarajaPankaj TalwarBhaskar MukherjeeBarun Kumar ChakrabartyBackground: Premature luteinization (PL) is defined as a premature rise in serum progesterone concentration on or before the day of ovulation trigger with human chorionic gonadotropin. The incidence of PL varies between 5% and 30% during in vitro fertilization and embryo transfer (IVF-ET). Materials and Methods: The prospective observational study comprising 380 patients undergoing IVF-ET. Blood samples were collected for serum progesterone level estimation on the day of ovulation trigger. Ovum pickup was done 36 h later and serum progesterone levels were correlated with IVF-ET outcome. Study Outcome: To correlate serum progesterone level on the day of ovulation trigger during IVF and its effect on treatment outcome. Results: Mean serum progesterone level in the positive pregnancy group and negative pregnancy group was 0.892 ± 0.752 ng/ml and 0.91 ± 0.688 ng/ml, respectively (P = 0.961). The overall incidence of PL was 12.8% with 12.7% and 13.6% in the agonist and antagonist protocol respectively (P = 0.9001). PL incidence was 13.5% and 13.4% in positive pregnancy and negative pregnancy group (P = 0.223). Conclusion: PL has been associated with 12.8% of the IVF cycles. There was no statistically significant difference observed in the incidence of PL between different IVF stimulation protocols. PL does not seem to affect IVF outcome.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=2;spage=136;epage=140;aulast=NagarajaDecreased ovarian reservehuman chorionic gonadotropinin vitro fertilizationpolycystic ovarian syndromepremature luteinization |
| spellingShingle | N Nagaraja Pankaj Talwar Bhaskar Mukherjee Barun Kumar Chakrabarty Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome Journal of Human Reproductive Sciences Decreased ovarian reserve human chorionic gonadotropin in vitro fertilization polycystic ovarian syndrome premature luteinization |
| title | Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome |
| title_full | Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome |
| title_fullStr | Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome |
| title_full_unstemmed | Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome |
| title_short | Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome |
| title_sort | correlation between serum progesterone level on the day of ovulation trigger during in vitro fertilization and its effect on treatment outcome |
| topic | Decreased ovarian reserve human chorionic gonadotropin in vitro fertilization polycystic ovarian syndrome premature luteinization |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=2;spage=136;epage=140;aulast=Nagaraja |
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