Validity of D-penicillamine in experimental cerebral vasospasm therapy
Background: Cerebral vasospasm is a reversible vessel constriction following subarachnoid hemorrhage. Immunoreactive and inflammatory mechanisms induce long-term vasoconstriction and vessel dilatation inhibition. We hypothesized that D-penicillamine depresses this process given that it reduces the c...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
|
| Series: | Interdisciplinary Neurosurgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214751923002001 |
| _version_ | 1797259943379730432 |
|---|---|
| author | Ersin Haciyakupoglu Evren Yüvrük Sebahattin Haciyakupoglu Milos Arsenovic Erol Akgül Dervis Mansuri Yilmaz Sait Polat |
| author_facet | Ersin Haciyakupoglu Evren Yüvrük Sebahattin Haciyakupoglu Milos Arsenovic Erol Akgül Dervis Mansuri Yilmaz Sait Polat |
| author_sort | Ersin Haciyakupoglu |
| collection | DOAJ |
| description | Background: Cerebral vasospasm is a reversible vessel constriction following subarachnoid hemorrhage. Immunoreactive and inflammatory mechanisms induce long-term vasoconstriction and vessel dilatation inhibition. We hypothesized that D-penicillamine depresses this process given that it reduces the concentration of free oxygen (O2) radicals. We evaluated the effects of D-penicillamine on cerebral vasospasm in rabbits induced with subarachnoid hemorrhage, achieved by autologous blood injection in the basal cistern. Materials and methods: Four experimental groups were studied: Group 1: basilar angiography, Group 2: basilar angiography + D-penicillamine, Group 3: subarachnoid hemorrhage (SAH), and Group 4: SAH + D-penicillamine. Vessel diameter and cerebral vasospasm were evaluated angiographically in each group. Vascular degeneration was studied by electron microscopy of the basilar artery. Free O2 radicals were investigated based on measurements of the levels of vascular superoxide dismutase and malondialdehyde. Myasthenia gravis–like side effects of D-penicillamine application were analyzed by electromyography and electron microscopy of the orbicularis oculi muscle. Results: We detected a 9.03% decrease in basilar artery constriction in Group 4 compared with Group 3. In addition, levels of free O2 radicals were reduced in Groups 2 and 4. Application of D-penicillamine resulted in the prevention of basilar artery wall degeneration, without myasthenia gravis–like side effects. Conclusion: Our study indicated that D-penicillamine application induced vasodilatation and had anti-inflammatory effects. |
| first_indexed | 2024-03-09T07:34:26Z |
| format | Article |
| id | doaj.art-9618a9857132474c9e6cb3632929b953 |
| institution | Directory Open Access Journal |
| issn | 2214-7519 |
| language | English |
| last_indexed | 2024-04-24T23:17:27Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj.art-9618a9857132474c9e6cb3632929b9532024-03-17T07:54:12ZengElsevierInterdisciplinary Neurosurgery2214-75192024-06-0136101917Validity of D-penicillamine in experimental cerebral vasospasm therapyErsin Haciyakupoglu0Evren Yüvrük1Sebahattin Haciyakupoglu2Milos Arsenovic3Erol Akgül4Dervis Mansuri Yilmaz5Sait Polat6Department of Neurosurgery, Heinrich-Braun-Klinikum Zwickau, Zwickau, GermanyDepartment of Neurosurgery, Umraniye Education and Research Hospital, Umraniye/Istanbul, TurkeyDepartment of Neurosurgery, Acibadem University, Adana, TurkeyDepartment of Neurosurgery, Heinrich-Braun-Klinikum Zwickau, Zwickau, Germany; Corresponding author at: Department of Neurosurgery, Heinrich-Braun-Klinikum, Karl-Keil-Strasse 35, Zwickau 08060, Germany.Department of Radiology, Cukurova University, Adana, TurkeyDepartment of Neurosurgery, Cukurova University, Adana, TurkeyDepartment of Histology, Cukurova University, Adana, TurkeyBackground: Cerebral vasospasm is a reversible vessel constriction following subarachnoid hemorrhage. Immunoreactive and inflammatory mechanisms induce long-term vasoconstriction and vessel dilatation inhibition. We hypothesized that D-penicillamine depresses this process given that it reduces the concentration of free oxygen (O2) radicals. We evaluated the effects of D-penicillamine on cerebral vasospasm in rabbits induced with subarachnoid hemorrhage, achieved by autologous blood injection in the basal cistern. Materials and methods: Four experimental groups were studied: Group 1: basilar angiography, Group 2: basilar angiography + D-penicillamine, Group 3: subarachnoid hemorrhage (SAH), and Group 4: SAH + D-penicillamine. Vessel diameter and cerebral vasospasm were evaluated angiographically in each group. Vascular degeneration was studied by electron microscopy of the basilar artery. Free O2 radicals were investigated based on measurements of the levels of vascular superoxide dismutase and malondialdehyde. Myasthenia gravis–like side effects of D-penicillamine application were analyzed by electromyography and electron microscopy of the orbicularis oculi muscle. Results: We detected a 9.03% decrease in basilar artery constriction in Group 4 compared with Group 3. In addition, levels of free O2 radicals were reduced in Groups 2 and 4. Application of D-penicillamine resulted in the prevention of basilar artery wall degeneration, without myasthenia gravis–like side effects. Conclusion: Our study indicated that D-penicillamine application induced vasodilatation and had anti-inflammatory effects.http://www.sciencedirect.com/science/article/pii/S2214751923002001D-penicillamineMicro vasospasmCerebral vasospasmSubarachnoid hemorrhageOxygen radical |
| spellingShingle | Ersin Haciyakupoglu Evren Yüvrük Sebahattin Haciyakupoglu Milos Arsenovic Erol Akgül Dervis Mansuri Yilmaz Sait Polat Validity of D-penicillamine in experimental cerebral vasospasm therapy Interdisciplinary Neurosurgery D-penicillamine Micro vasospasm Cerebral vasospasm Subarachnoid hemorrhage Oxygen radical |
| title | Validity of D-penicillamine in experimental cerebral vasospasm therapy |
| title_full | Validity of D-penicillamine in experimental cerebral vasospasm therapy |
| title_fullStr | Validity of D-penicillamine in experimental cerebral vasospasm therapy |
| title_full_unstemmed | Validity of D-penicillamine in experimental cerebral vasospasm therapy |
| title_short | Validity of D-penicillamine in experimental cerebral vasospasm therapy |
| title_sort | validity of d penicillamine in experimental cerebral vasospasm therapy |
| topic | D-penicillamine Micro vasospasm Cerebral vasospasm Subarachnoid hemorrhage Oxygen radical |
| url | http://www.sciencedirect.com/science/article/pii/S2214751923002001 |
| work_keys_str_mv | AT ersinhaciyakupoglu validityofdpenicillamineinexperimentalcerebralvasospasmtherapy AT evrenyuvruk validityofdpenicillamineinexperimentalcerebralvasospasmtherapy AT sebahattinhaciyakupoglu validityofdpenicillamineinexperimentalcerebralvasospasmtherapy AT milosarsenovic validityofdpenicillamineinexperimentalcerebralvasospasmtherapy AT erolakgul validityofdpenicillamineinexperimentalcerebralvasospasmtherapy AT dervismansuriyilmaz validityofdpenicillamineinexperimentalcerebralvasospasmtherapy AT saitpolat validityofdpenicillamineinexperimentalcerebralvasospasmtherapy |