Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series
The novel SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2) is now known to cause acute respiratory distress, cytokine storm, and coagulopathy. Multiple other manifestations have been published in recent literature. Rhabdomyolysis is a syndrome of muscle damage, with release of intr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-12-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/2324709620984603 |
| _version_ | 1818323249588600832 |
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| author | Shikha G. Khosla MD Eric S. Nylen MD Rahul Khosla MD |
| author_facet | Shikha G. Khosla MD Eric S. Nylen MD Rahul Khosla MD |
| author_sort | Shikha G. Khosla MD |
| collection | DOAJ |
| description | The novel SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2) is now known to cause acute respiratory distress, cytokine storm, and coagulopathy. Multiple other manifestations have been published in recent literature. Rhabdomyolysis is a syndrome of muscle damage, with release of intracellular contents into circulation. It is characterized by marked elevations of creatinine kinase levels and myoglobinuria. In this article, we describe a series of 5 cases who were admitted with COVID-19 pneumonia and had severe muscle injury, as demonstrated by significant elevation (>5 times upper limit of normal) of creatinine kinase levels likely secondary to SARS-CoV-2 virus. The median age for these patients was 65 years, and most of them suffered from diabetes and hyperlipidemia. All patients were hypertensive males. Four out of 5 patients had preserved kidney function at baseline and were chronic kidney disease (CKD) stage 2 or better. However, most of them suffered significant kidney injury and at the time of discharge one patient was CKD stage 2 or better, 2 were CKD stage 3 or worse, and 2 patients had renal failure and died due to complications of SARS-CoV-2 infection. |
| first_indexed | 2024-12-13T11:09:42Z |
| format | Article |
| id | doaj.art-9618d8fc5e944a5798ef4e9edb5a89b3 |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-13T11:09:42Z |
| publishDate | 2020-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-9618d8fc5e944a5798ef4e9edb5a89b32022-12-21T23:48:48ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962020-12-01810.1177/2324709620984603Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case SeriesShikha G. Khosla MD0Eric S. Nylen MD1Rahul Khosla MD2George Washington University, Washington, DC, USAGeorge Washington University, Washington, DC, USAGeorge Washington University, Washington, DC, USAThe novel SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2) is now known to cause acute respiratory distress, cytokine storm, and coagulopathy. Multiple other manifestations have been published in recent literature. Rhabdomyolysis is a syndrome of muscle damage, with release of intracellular contents into circulation. It is characterized by marked elevations of creatinine kinase levels and myoglobinuria. In this article, we describe a series of 5 cases who were admitted with COVID-19 pneumonia and had severe muscle injury, as demonstrated by significant elevation (>5 times upper limit of normal) of creatinine kinase levels likely secondary to SARS-CoV-2 virus. The median age for these patients was 65 years, and most of them suffered from diabetes and hyperlipidemia. All patients were hypertensive males. Four out of 5 patients had preserved kidney function at baseline and were chronic kidney disease (CKD) stage 2 or better. However, most of them suffered significant kidney injury and at the time of discharge one patient was CKD stage 2 or better, 2 were CKD stage 3 or worse, and 2 patients had renal failure and died due to complications of SARS-CoV-2 infection.https://doi.org/10.1177/2324709620984603 |
| spellingShingle | Shikha G. Khosla MD Eric S. Nylen MD Rahul Khosla MD Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series Journal of Investigative Medicine High Impact Case Reports |
| title | Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series |
| title_full | Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series |
| title_fullStr | Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series |
| title_full_unstemmed | Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series |
| title_short | Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series |
| title_sort | rhabdomyolysis in patients hospitalized with covid 19 infection five case series |
| url | https://doi.org/10.1177/2324709620984603 |
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