Serum Sphingosine‐1‐Phosphate Is Decreased in Patients With Acute‐on‐Chronic Liver Failure and Predicts Early Mortality

Serum Sphingosine‐1‐Phosphate Is Decreased in Patients With Acute‐on‐Chronic Liver Failure and Predicts Early Mortality

Sphingosine‐1‐phosphate (S1P) regulates pathophysiological processes, including liver regeneration, vascular tone control, and immune response. In patients with liver cirrhosis, acute deterioration of liver function is associated with high mortality rates. The present study investigated whether seru...

Full description

Bibliographic Details
Main Authors:	Victoria T. Mücke, Katharina Maria Schwarzkopf, Dominique Thomas, Marcus M. Mücke, Sabrina Rüschenbaum, Jonel Trebicka, Josef Pfeilschifter, Stefan Zeuzem, Christian M. Lange, Georgios Grammatikos
Format:	Article
Language:	English
Published:	Wolters Kluwer Health/LWW 2020-10-01
Series:	Hepatology Communications
Online Access:	https://doi.org/10.1002/hep4.1561

Similar Items

Serum sphingolipid levels associate with upcoming virologic events and HBV genotype D in a cohort of patients with HBeAg-negative HBV infection.
by: Victoria Therese Mücke, et al.
Published: (2018-01-01)

Sphingosine 1-Phosphate in Renal Diseases
by: Alexander Koch, et al.
Published: (2013-05-01)

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis.
by: Alexander Queck, et al.
Published: (2019-01-01)

Use of Antiplatelet Agents Is Inversely Associated With Liver Fibrosis in Patients With Cardiovascular Disease
by: Katharina Schwarzkopf, et al.
Published: (2018-12-01)

The role of Enterococcus spp. and multidrug-resistant bacteria causing pyogenic liver abscesses
by: Marcus M. Mücke, et al.
Published: (2017-06-01)

Impact of colonization with multidrug-resistant organisms on antibiotic prophylaxis in patients with cirrhosis and variceal bleeding
by: Victoria T. Mücke, et al.
Published: (2022-01-01)

Impact of colonization with multidrug-resistant organisms on antibiotic prophylaxis in patients with cirrhosis and variceal bleeding.
by: Victoria T Mücke, et al.
Published: (2022-01-01)

First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report
by: Victoria Therese Mücke, et al.
Published: (2021-09-01)

Hypopituitarism in Wilson’s disease resolved after copper-chelating therapy
by: Nina Dauth, et al.
Published: (2021-01-01)

The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure
by: Marcus M. Mücke, et al.
Published: (2024-01-01)

Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19
by: Giovanni Marfia, et al.
Published: (2021-01-01)

Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro
by: Katja Jakobi, et al.
Published: (2020-03-01)

A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke
by: Alexandra Lucaciu, et al.
Published: (2020-08-01)

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis
by: Kana Masuda-Kuroki, et al.
Published: (2023-09-01)

Serum sphingosine-1-phosphate levels and Sphingosine-1-Phosphate gene polymorphisms in acute respiratory distress syndrome: a multicenter prospective study
by: Jiangnan Zhao, et al.
Published: (2020-04-01)

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets
by: Motohiro Tani, et al.
Published: (2005-11-01)

Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts
by: Katja Ihlefeld, et al.
Published: (2015-01-01)

Serum Sphingosine-1-phosphate level and peritonitis in peritoneal dialysis patients
by: Qiong Bai, et al.
Published: (2020-01-01)

Sphingosine 1-Phosphate Receptor 5 (S1P<sub>5</sub>) Knockout Ameliorates Adenine-Induced Nephropathy
by: Timon Eckes, et al.
Published: (2022-04-01)

Retraction Note: Serum sphingosine-1-phosphate levels and Sphingosine-1-Phosphate gene polymorphisms in acute respiratory distress syndrome: a multicenter prospective study
by: Jiangnan Zhao, et al.
Published: (2022-12-01)

Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans.
by: Irina Soltau, et al.
Published: (2016-01-01)

Anemia and Systemic Inflammation Rather than Arterial Circulatory Dysfunction Predict Decompensation of Liver Cirrhosis
by: Christina Bothou, et al.
Published: (2020-04-01)

Patatin‐like phospholipase domain containing 3 variants differentially impact metabolic traits in individuals at high risk for cardiovascular events
by: Sabrina Rüschenbaum, et al.
Published: (2018-07-01)

Irisin Is Target of Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor-Mediated Signaling in Skeletal Muscle Cells
by: Federica Pierucci, et al.
Published: (2023-06-01)

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System
by: Alessandro Cannavo, et al.
Published: (2017-08-01)

Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation.
by: Katharina Maria Schwarzkopf, et al.
Published: (2019-01-01)

Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis: A Matter of Inflammation
by: Moritz E, et al.
Published: (2021-06-01)

Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1
by: Amin Polzin, et al.
Published: (2023-02-01)

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2*
by: Hitoshi Ikeda, et al.
Published: (2009-03-01)

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia.
by: Aneta Dobierzewska, et al.
Published: (2016-01-01)

Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels.
by: Kirsi Riento, et al.
Published: (2018-01-01)

Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study
by: Katrin G. Schmidt, et al.
Published: (2017-09-01)

Vitamin D deficiency is associated with hepatic decompensation and inflammation in patients with liver cirrhosis: A prospective cohort study.
by: Alica Kubesch, et al.
Published: (2018-01-01)

Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases
by: Na Wang, et al.
Published: (2023-05-01)

Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency
by: Krishan B. Atreya, et al.
Published: (2022-09-01)

Sphingosine-1-Phosphate: Boon and Bane for the Brain
by: Gerhild van Echten-Deckert, et al.
Published: (2014-06-01)

Roles of sphingosine-1-phosphate signaling in cancer
by: Peng Wang, et al.
Published: (2019-11-01)

Plasma sphingosine-1-phosphate is elevated in obesity.
by: Greg M Kowalski, et al.
Published: (2013-01-01)

Export of sphingosine-1-phosphate and cancer progression
by: Kazuaki Takabe, et al.
Published: (2014-09-01)

Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase.
by: Timo Heckt, et al.
Published: (2019-01-01)