Interval timing and time-based decision making requires differential protein synthesis in the dorsal and ventral striatum for the setting of ‘Start’ and ‘Stop’ response thresholds
Time-based decision-making in peak-interval timing procedures involves the setting of response thresholds for the initiation (‘Start’) and termination (‘Stop’) of a response sequence that is centered on the target duration. We report here that the acquisition of the ‘Start’ response depends on de no...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-03-01
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| Series: | Frontiers in Integrative Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnint.2012.00010/full |
| _version_ | 1811209691889401856 |
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| author | Christopher eMacDonald Ruey-Kuang eCheng Warren H Meck |
| author_facet | Christopher eMacDonald Ruey-Kuang eCheng Warren H Meck |
| author_sort | Christopher eMacDonald |
| collection | DOAJ |
| description | Time-based decision-making in peak-interval timing procedures involves the setting of response thresholds for the initiation (‘Start’) and termination (‘Stop’) of a response sequence that is centered on the target duration. We report here that the acquisition of the ‘Start’ response depends on de novo protein synthesis in the dorsal striatum (DS), but not the ventral striatum (VS). Conversely, inhibition of protein synthesis in the VS, but not the DS, impairs the acquisition of the ‘Stop’ response. The hypothesis is that the dorsal and ventral regions of the striatum function as a competitive neural network that encodes the temporal boundaries marking the beginning and end of a learned response sequence. |
| first_indexed | 2024-04-12T04:43:44Z |
| format | Article |
| id | doaj.art-961bc5e7f02045a98dcdb99c6ca4327a |
| institution | Directory Open Access Journal |
| issn | 1662-5145 |
| language | English |
| last_indexed | 2024-04-12T04:43:44Z |
| publishDate | 2012-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Integrative Neuroscience |
| spelling | doaj.art-961bc5e7f02045a98dcdb99c6ca4327a2022-12-22T03:47:33ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452012-03-01610.3389/fnint.2012.0001012630Interval timing and time-based decision making requires differential protein synthesis in the dorsal and ventral striatum for the setting of ‘Start’ and ‘Stop’ response thresholdsChristopher eMacDonald0Ruey-Kuang eCheng1Warren H Meck2Boston UniversityA*STARDuke UniversityTime-based decision-making in peak-interval timing procedures involves the setting of response thresholds for the initiation (‘Start’) and termination (‘Stop’) of a response sequence that is centered on the target duration. We report here that the acquisition of the ‘Start’ response depends on de novo protein synthesis in the dorsal striatum (DS), but not the ventral striatum (VS). Conversely, inhibition of protein synthesis in the VS, but not the DS, impairs the acquisition of the ‘Stop’ response. The hypothesis is that the dorsal and ventral regions of the striatum function as a competitive neural network that encodes the temporal boundaries marking the beginning and end of a learned response sequence.http://journal.frontiersin.org/Journal/10.3389/fnint.2012.00010/fullbasal ganglia circuitsprotein synthesisTiming and Time perceptiondopamine-glutamate interactionsreward anticipation |
| spellingShingle | Christopher eMacDonald Ruey-Kuang eCheng Warren H Meck Interval timing and time-based decision making requires differential protein synthesis in the dorsal and ventral striatum for the setting of ‘Start’ and ‘Stop’ response thresholds Frontiers in Integrative Neuroscience basal ganglia circuits protein synthesis Timing and Time perception dopamine-glutamate interactions reward anticipation |
| title | Interval timing and time-based decision making requires differential protein synthesis in the dorsal and ventral striatum for the setting of ‘Start’ and ‘Stop’ response thresholds |
| title_full | Interval timing and time-based decision making requires differential protein synthesis in the dorsal and ventral striatum for the setting of ‘Start’ and ‘Stop’ response thresholds |
| title_fullStr | Interval timing and time-based decision making requires differential protein synthesis in the dorsal and ventral striatum for the setting of ‘Start’ and ‘Stop’ response thresholds |
| title_full_unstemmed | Interval timing and time-based decision making requires differential protein synthesis in the dorsal and ventral striatum for the setting of ‘Start’ and ‘Stop’ response thresholds |
| title_short | Interval timing and time-based decision making requires differential protein synthesis in the dorsal and ventral striatum for the setting of ‘Start’ and ‘Stop’ response thresholds |
| title_sort | interval timing and time based decision making requires differential protein synthesis in the dorsal and ventral striatum for the setting of start and stop response thresholds |
| topic | basal ganglia circuits protein synthesis Timing and Time perception dopamine-glutamate interactions reward anticipation |
| url | http://journal.frontiersin.org/Journal/10.3389/fnint.2012.00010/full |
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