High glucose induces CCL20 in proximal tubular cells via activation of the KCa3.1 channel.

High glucose induces CCL20 in proximal tubular cells via activation of the KCa3.1 channel.

BACKGROUND: Inflammation plays a key role in the development and progression of diabetic nephropathy (DN). KCa3.1, a calcium activated potassium channel protein, is associated with vascular inflammation, atherogenesis, and proliferation of endothelial cells, macrophages, and fibroblasts. We have pre...

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Bibliographic Details
Main Authors: Chunling Huang, Carol A Pollock, Xin-Ming Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3986377?pdf=render

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