INVESTIGATION PHYLOGENETIC RELATIONSHIPS MAJOR GENOTYPES MYCOBACTERIUM TUBERCULOSIS BY MIRU-VNTR-24 GENOTYPING
Thirty-one isolates of M. tuberculosis was identified in Buryatia by MIRU-VNTR-24 typing and deletion analysis by RD105 and RD207. Beijing family strains accountedfor 67,4 % and had a variety of profiles with a prevalence (22,6 %) of two modern epidemic subtype Beijing MIT17 and MIT16. Strains Beiji...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2013-04-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/1464 |
| _version_ | 1797237561809174528 |
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| author | A. A. Lats O. B. Ogarkov S. N. Zhdanova A. N. Zarbuev L. S. Untanova M. V. Badleeva B. D. Zanaeva O. Ts. Tsydypova |
| author_facet | A. A. Lats O. B. Ogarkov S. N. Zhdanova A. N. Zarbuev L. S. Untanova M. V. Badleeva B. D. Zanaeva O. Ts. Tsydypova |
| author_sort | A. A. Lats |
| collection | DOAJ |
| description | Thirty-one isolates of M. tuberculosis was identified in Buryatia by MIRU-VNTR-24 typing and deletion analysis by RD105 and RD207. Beijing family strains accountedfor 67,4 % and had a variety of profiles with a prevalence (22,6 %) of two modern epidemic subtype Beijing MIT17 and MIT16. Strains Beijing MIT 642 differed in the number of repeats of the variable loci, it may reflect a longer circulation of these subtypes without shaping their properties of epidemic circulating strains in modern populations, or they had epidemic importance in the past. It is also apparent heterogeneity in the number of loci among strains according to group LAM, T, and X, which requires additional research. The aim of this work was to determine the current epidemiologically important genotypes of Mycobacterium tuberculosis, as well as the genotypes had an epidemic importance in the past as an example of the region with a high prevalence of tuberculosis - the Republic of Buryatia. |
| first_indexed | 2024-03-08T12:21:03Z |
| format | Article |
| id | doaj.art-961f9b87e583455eb0020a7de95bc94c |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:21:43Z |
| publishDate | 2013-04-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-961f9b87e583455eb0020a7de95bc94c2024-03-28T07:49:10ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962013-04-0102(2)1441471410INVESTIGATION PHYLOGENETIC RELATIONSHIPS MAJOR GENOTYPES MYCOBACTERIUM TUBERCULOSIS BY MIRU-VNTR-24 GENOTYPINGA. A. Lats0O. B. Ogarkov1S. N. Zhdanova2A. N. Zarbuev3L. S. Untanova4M. V. Badleeva5B. D. Zanaeva6O. Ts. Tsydypova7Scientific Centre of the Family Health and Human Reproduction Problems Siberian Branch, Russian Academy of Medical SciencesScientific Centre of the Family Health and Human Reproduction Problems Siberian Branch, Russian Academy of Medical SciencesScientific Centre of the Family Health and Human Reproduction Problems Siberian Branch, Russian Academy of Medical SciencesRepublican Clinical TB DispensaryRepublican Clinical TB DispensaryBuryatian State UniversityScientific Centre of the Family Health and Human Reproduction Problems Siberian Branch, Russian Academy of Medical SciencesScientific Centre of the Family Health and Human Reproduction Problems Siberian Branch, Russian Academy of Medical SciencesThirty-one isolates of M. tuberculosis was identified in Buryatia by MIRU-VNTR-24 typing and deletion analysis by RD105 and RD207. Beijing family strains accountedfor 67,4 % and had a variety of profiles with a prevalence (22,6 %) of two modern epidemic subtype Beijing MIT17 and MIT16. Strains Beijing MIT 642 differed in the number of repeats of the variable loci, it may reflect a longer circulation of these subtypes without shaping their properties of epidemic circulating strains in modern populations, or they had epidemic importance in the past. It is also apparent heterogeneity in the number of loci among strains according to group LAM, T, and X, which requires additional research. The aim of this work was to determine the current epidemiologically important genotypes of Mycobacterium tuberculosis, as well as the genotypes had an epidemic importance in the past as an example of the region with a high prevalence of tuberculosis - the Republic of Buryatia.https://www.actabiomedica.ru/jour/article/view/1464molecular epidemiology of tuberculosispandemic genotype m. tuberculosisreconstruction of the history epidemicphylogeny |
| spellingShingle | A. A. Lats O. B. Ogarkov S. N. Zhdanova A. N. Zarbuev L. S. Untanova M. V. Badleeva B. D. Zanaeva O. Ts. Tsydypova INVESTIGATION PHYLOGENETIC RELATIONSHIPS MAJOR GENOTYPES MYCOBACTERIUM TUBERCULOSIS BY MIRU-VNTR-24 GENOTYPING Acta Biomedica Scientifica molecular epidemiology of tuberculosis pandemic genotype m. tuberculosis reconstruction of the history epidemic phylogeny |
| title | INVESTIGATION PHYLOGENETIC RELATIONSHIPS MAJOR GENOTYPES MYCOBACTERIUM TUBERCULOSIS BY MIRU-VNTR-24 GENOTYPING |
| title_full | INVESTIGATION PHYLOGENETIC RELATIONSHIPS MAJOR GENOTYPES MYCOBACTERIUM TUBERCULOSIS BY MIRU-VNTR-24 GENOTYPING |
| title_fullStr | INVESTIGATION PHYLOGENETIC RELATIONSHIPS MAJOR GENOTYPES MYCOBACTERIUM TUBERCULOSIS BY MIRU-VNTR-24 GENOTYPING |
| title_full_unstemmed | INVESTIGATION PHYLOGENETIC RELATIONSHIPS MAJOR GENOTYPES MYCOBACTERIUM TUBERCULOSIS BY MIRU-VNTR-24 GENOTYPING |
| title_short | INVESTIGATION PHYLOGENETIC RELATIONSHIPS MAJOR GENOTYPES MYCOBACTERIUM TUBERCULOSIS BY MIRU-VNTR-24 GENOTYPING |
| title_sort | investigation phylogenetic relationships major genotypes mycobacterium tuberculosis by miru vntr 24 genotyping |
| topic | molecular epidemiology of tuberculosis pandemic genotype m. tuberculosis reconstruction of the history epidemic phylogeny |
| url | https://www.actabiomedica.ru/jour/article/view/1464 |
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