Distinct Effector Programs of Brain-Homing CD8<sup>+</sup> T Cells in Multiple Sclerosis

Distinct Effector Programs of Brain-Homing CD8<sup>+</sup> T Cells in Multiple Sclerosis

The effector programs of CD8<sup>+</sup> memory T cells are influenced by the transcription factors RUNX3, EOMES and T-bet. How these factors define brain-homing CD8<sup>+</sup> memory T cells in multiple sclerosis (MS) remains unknown. To address this, we analyzed blood, CSF...

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Bibliographic Details
Main Authors: Steven C. Koetzier, Jamie van Langelaar, Marie-José Melief, Annet F. Wierenga-Wolf, Cato E. A. Corsten, Katelijn M. Blok, Cindy Hoeks, Bieke Broux, Beatrijs Wokke, Marvin M. van Luijn, Joost Smolders
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
transcription factors
cytotoxicity
pre-existing and brain-residency
Online Access:https://www.mdpi.com/2073-4409/11/10/1634

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