A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2)
Acute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2012-12-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | http://acta.tums.ac.ir/index.php/acta/article/view/4600/4279 |
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| author | Hanumanthappa Vijay Raghavendra Madaiah Mahadeva Prasad Danem Satienariana Madhumathi Maiana Mangalagowri Chintaparthi Obula Reddy Bidadi LingappaKavitha Prasanna Kumari Chennagiri Shinivasa Murthy Premalata Kuntejowdahalli Channaviriappa Lakshmaiah Seyed Hashem Mir Mazloumi |
| author_facet | Hanumanthappa Vijay Raghavendra Madaiah Mahadeva Prasad Danem Satienariana Madhumathi Maiana Mangalagowri Chintaparthi Obula Reddy Bidadi LingappaKavitha Prasanna Kumari Chennagiri Shinivasa Murthy Premalata Kuntejowdahalli Channaviriappa Lakshmaiah Seyed Hashem Mir Mazloumi |
| author_sort | Hanumanthappa Vijay Raghavendra |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult cases of this category with unusual karyotype. Bone marrow cytogenetics of case no. 1: 45,X,-Y, t(8;21)(q13;q22) with a novel breakpoint of chromosome 8 at (q13). Case no. 2: 46,X,t(X;2)(q22;q37),t(3;7)(q21;q36),t(5;14)(p15;q11),del(8)(q22) a complex rearrangement without the involvement of chromosome 21. Case no. 3: 49,XX,+5, t(8;21)(q22;q22), +16, +der(21)t(8;21)(q22;q22) with additional der(21). Endometrial in this case which was positive for myeloperoxidase (MPO) and CD117 conforming the AML infiltration. All are morphologically AML with t(8;21). Relevant literature in cytogenetic of AML-M2 is reviewed. The molecular mechanism involved in unusual rearrangements and clinical significance of them are subjected for further studies |
| first_indexed | 2024-12-19T04:23:22Z |
| format | Article |
| id | doaj.art-96225c5e4a6a4785918c4a3601e55f0e |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-19T04:23:22Z |
| publishDate | 2012-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-96225c5e4a6a4785918c4a3601e55f0e2022-12-21T20:36:05ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942012-12-015012827830A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2)Hanumanthappa Vijay RaghavendraMadaiah Mahadeva PrasadDanem Satienariana MadhumathiMaiana MangalagowriChintaparthi Obula ReddyBidadi LingappaKavithaPrasanna KumariChennagiri Shinivasa Murthy PremalataKuntejowdahalli Channaviriappa LakshmaiahSeyed Hashem Mir MazloumiAcute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult cases of this category with unusual karyotype. Bone marrow cytogenetics of case no. 1: 45,X,-Y, t(8;21)(q13;q22) with a novel breakpoint of chromosome 8 at (q13). Case no. 2: 46,X,t(X;2)(q22;q37),t(3;7)(q21;q36),t(5;14)(p15;q11),del(8)(q22) a complex rearrangement without the involvement of chromosome 21. Case no. 3: 49,XX,+5, t(8;21)(q22;q22), +16, +der(21)t(8;21)(q22;q22) with additional der(21). Endometrial in this case which was positive for myeloperoxidase (MPO) and CD117 conforming the AML infiltration. All are morphologically AML with t(8;21). Relevant literature in cytogenetic of AML-M2 is reviewed. The molecular mechanism involved in unusual rearrangements and clinical significance of them are subjected for further studieshttp://acta.tums.ac.ir/index.php/acta/article/view/4600/4279Acute Myeloid LeukemiaBreakpointComplex KaryotypeVariant |
| spellingShingle | Hanumanthappa Vijay Raghavendra Madaiah Mahadeva Prasad Danem Satienariana Madhumathi Maiana Mangalagowri Chintaparthi Obula Reddy Bidadi LingappaKavitha Prasanna Kumari Chennagiri Shinivasa Murthy Premalata Kuntejowdahalli Channaviriappa Lakshmaiah Seyed Hashem Mir Mazloumi A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) Acta Medica Iranica Acute Myeloid Leukemia Breakpoint Complex Karyotype Variant |
| title | A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) |
| title_full | A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) |
| title_fullStr | A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) |
| title_full_unstemmed | A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) |
| title_short | A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) |
| title_sort | rare cytogenetic presentation of acute myeloid leukemia aml m2 |
| topic | Acute Myeloid Leukemia Breakpoint Complex Karyotype Variant |
| url | http://acta.tums.ac.ir/index.php/acta/article/view/4600/4279 |
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