SCONCE2: jointly inferring single cell copy number profiles and tumor evolutionary distances

SCONCE2: jointly inferring single cell copy number profiles and tumor evolutionary distances

Abstract Background Single cell whole genome tumor sequencing can yield novel insights into the evolutionary history of somatic copy number alterations. Existing single cell copy number calling methods do not explicitly model the shared evolutionary process of multiple cells, and generally analyze c...

Full description

Bibliographic Details
Main Authors: Sandra Hui, Rasmus Nielsen
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Bioinformatics
Subjects:
Copy number alterations
Cancer genomics
Single cell sequencing
Tumor evolution
Tumor phylogenies
Online Access:https://doi.org/10.1186/s12859-022-04890-w

Internet

https://doi.org/10.1186/s12859-022-04890-w

Similar Items