Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis
Abstract Background The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies. Methods Systematic searches of the PubMed, Web of Scie...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-04-01
|
| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12935-019-0788-z |
| _version_ | 1811223924812283904 |
|---|---|
| author | Jiayi Zhang Aiming Xu Chenkui Miao Jie Yang Min Gu Ninghong Song |
| author_facet | Jiayi Zhang Aiming Xu Chenkui Miao Jie Yang Min Gu Ninghong Song |
| author_sort | Jiayi Zhang |
| collection | DOAJ |
| description | Abstract Background The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies. Methods Systematic searches of the PubMed, Web of Science and Embase were used to identify relevant studies. Pooled hazard ratios (HRs) with 95% confidence intervals (CI) for overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), or progression-free survival (PFS) were respectively calculated. Results 3772 Lin28A-associated patients and 1730 Lin28B-related cases were ultimately enrolled in this meta-analysis. The elevated expression level of Lin28A was significantly associated with poor OS (HR = 1.60, P < 0.001) and poor RFS/DFS/PFS (HR = 1.62, P < 0.001) in patients with malignancies. Lin28B overexpression significantly correlated with unfavorable OS (HR = 1.72, P < 0.001) and RFS/DFS/PFS (HR = 2.35, P < 0.001) of human malignancies. Conclusions Lin28A and Lin28B possess significant prognostic values in various human malignancies. Overexpression of Lin28A or Lin28B suggests poor prognosis for cancer patients. |
| first_indexed | 2024-04-12T08:41:54Z |
| format | Article |
| id | doaj.art-9622e6b7d6364adf9b6dace76831f79c |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-12T08:41:54Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-9622e6b7d6364adf9b6dace76831f79c2022-12-22T03:39:51ZengBMCCancer Cell International1475-28672019-04-011911810.1186/s12935-019-0788-zPrognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysisJiayi Zhang0Aiming Xu1Chenkui Miao2Jie Yang3Min Gu4Ninghong Song5Department of Urology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Nanjing Medical UniversityAbstract Background The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies. Methods Systematic searches of the PubMed, Web of Science and Embase were used to identify relevant studies. Pooled hazard ratios (HRs) with 95% confidence intervals (CI) for overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), or progression-free survival (PFS) were respectively calculated. Results 3772 Lin28A-associated patients and 1730 Lin28B-related cases were ultimately enrolled in this meta-analysis. The elevated expression level of Lin28A was significantly associated with poor OS (HR = 1.60, P < 0.001) and poor RFS/DFS/PFS (HR = 1.62, P < 0.001) in patients with malignancies. Lin28B overexpression significantly correlated with unfavorable OS (HR = 1.72, P < 0.001) and RFS/DFS/PFS (HR = 2.35, P < 0.001) of human malignancies. Conclusions Lin28A and Lin28B possess significant prognostic values in various human malignancies. Overexpression of Lin28A or Lin28B suggests poor prognosis for cancer patients.http://link.springer.com/article/10.1186/s12935-019-0788-zLin-28PrognosisHuman tumorsBiomarkerMeta-analysis |
| spellingShingle | Jiayi Zhang Aiming Xu Chenkui Miao Jie Yang Min Gu Ninghong Song Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis Cancer Cell International Lin-28 Prognosis Human tumors Biomarker Meta-analysis |
| title | Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis |
| title_full | Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis |
| title_fullStr | Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis |
| title_short | Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis |
| title_sort | prognostic value of lin28a and lin28b in various human malignancies a systematic review and meta analysis |
| topic | Lin-28 Prognosis Human tumors Biomarker Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12935-019-0788-z |
| work_keys_str_mv | AT jiayizhang prognosticvalueoflin28aandlin28binvarioushumanmalignanciesasystematicreviewandmetaanalysis AT aimingxu prognosticvalueoflin28aandlin28binvarioushumanmalignanciesasystematicreviewandmetaanalysis AT chenkuimiao prognosticvalueoflin28aandlin28binvarioushumanmalignanciesasystematicreviewandmetaanalysis AT jieyang prognosticvalueoflin28aandlin28binvarioushumanmalignanciesasystematicreviewandmetaanalysis AT mingu prognosticvalueoflin28aandlin28binvarioushumanmalignanciesasystematicreviewandmetaanalysis AT ninghongsong prognosticvalueoflin28aandlin28binvarioushumanmalignanciesasystematicreviewandmetaanalysis |