Astaxanthin suppresses the metastasis of clear cell renal cell carcinoma through ROS scavenging
Clear cell renal cell carcinoma (ccRCC) represents a prevalent form of kidney cancer, and its poor prognosis is closely tied to the occurrence of metastasis. ROS can drive epithelial-mesenchymal transition (EMT), thereby promoting cancer metastasis. Astaxanthin (AXT), renowned for its exceptional an...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624001415 |
| _version_ | 1831892776033189888 |
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| author | Jun Gong Suwei Jiang Yuanbing Huang Dongxin Yang Liang Zhang Zhenhai Li Qingzheng Kang |
| author_facet | Jun Gong Suwei Jiang Yuanbing Huang Dongxin Yang Liang Zhang Zhenhai Li Qingzheng Kang |
| author_sort | Jun Gong |
| collection | DOAJ |
| description | Clear cell renal cell carcinoma (ccRCC) represents a prevalent form of kidney cancer, and its poor prognosis is closely tied to the occurrence of metastasis. ROS can drive epithelial-mesenchymal transition (EMT), thereby promoting cancer metastasis. Astaxanthin (AXT), renowned for its exceptional antioxidant properties, has been shown in this study to suppress ccRCC metastasis by scavenging ROS. AXT dose-dependently reduced ROS levels and attenuated migratory and invasive capabilities of ccRCC cells. Additionally, ccRCC cells treated with AXT exhibited phenotypic characteristics indicating EMT inhibition, which was reflected by the increased E-cadherin and decreased vimentin. Furthermore, AXT-induced suppressed metastatic potential was also corroborated in mouse lung metastasis model. Notably, artificially elevating ROS levels reversed the AXT-induced reduction in migratory and invasive capacity. Taken together, these findings highlight the anti-metastatic function of AXT in ccRCC, suggesting its therapeutic potential in the management of ccRCC metastasis. |
| first_indexed | 2024-04-24T22:21:35Z |
| format | Article |
| id | doaj.art-9624cfc7e7514750986bec42b59aa70b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2025-03-22T01:28:35Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-9624cfc7e7514750986bec42b59aa70b2024-05-10T04:33:42ZengElsevierJournal of Functional Foods1756-46462024-05-01116106139Astaxanthin suppresses the metastasis of clear cell renal cell carcinoma through ROS scavengingJun Gong0Suwei Jiang1Yuanbing Huang2Dongxin Yang3Liang Zhang4Zhenhai Li5Qingzheng Kang6Central Laboratory of YunFu Peolple’s Hospital, YunFu Key Laboratory of Brain Diseases Research, Yunfu 527300, ChinaSchool of Medicine, Shenzhen University, Shenzhen 518060, ChinaCentral Laboratory of YunFu Peolple’s Hospital, YunFu Key Laboratory of Brain Diseases Research, Yunfu 527300, ChinaCentral Laboratory of YunFu Peolple’s Hospital, YunFu Key Laboratory of Brain Diseases Research, Yunfu 527300, ChinaHubei Superior Discipline Group of Exercise and Brain Science from Hubei Provincial, Wuhan Sports University, Wuhan 430079, China; Corresponding authors.Department of Hematology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China; Corresponding authors.Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, China, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518060, China.; Corresponding authors.Clear cell renal cell carcinoma (ccRCC) represents a prevalent form of kidney cancer, and its poor prognosis is closely tied to the occurrence of metastasis. ROS can drive epithelial-mesenchymal transition (EMT), thereby promoting cancer metastasis. Astaxanthin (AXT), renowned for its exceptional antioxidant properties, has been shown in this study to suppress ccRCC metastasis by scavenging ROS. AXT dose-dependently reduced ROS levels and attenuated migratory and invasive capabilities of ccRCC cells. Additionally, ccRCC cells treated with AXT exhibited phenotypic characteristics indicating EMT inhibition, which was reflected by the increased E-cadherin and decreased vimentin. Furthermore, AXT-induced suppressed metastatic potential was also corroborated in mouse lung metastasis model. Notably, artificially elevating ROS levels reversed the AXT-induced reduction in migratory and invasive capacity. Taken together, these findings highlight the anti-metastatic function of AXT in ccRCC, suggesting its therapeutic potential in the management of ccRCC metastasis.http://www.sciencedirect.com/science/article/pii/S1756464624001415Clear cell renal cell carcinomaROSAstaxanthinMetastasis |
| spellingShingle | Jun Gong Suwei Jiang Yuanbing Huang Dongxin Yang Liang Zhang Zhenhai Li Qingzheng Kang Astaxanthin suppresses the metastasis of clear cell renal cell carcinoma through ROS scavenging Journal of Functional Foods Clear cell renal cell carcinoma ROS Astaxanthin Metastasis |
| title | Astaxanthin suppresses the metastasis of clear cell renal cell carcinoma through ROS scavenging |
| title_full | Astaxanthin suppresses the metastasis of clear cell renal cell carcinoma through ROS scavenging |
| title_fullStr | Astaxanthin suppresses the metastasis of clear cell renal cell carcinoma through ROS scavenging |
| title_full_unstemmed | Astaxanthin suppresses the metastasis of clear cell renal cell carcinoma through ROS scavenging |
| title_short | Astaxanthin suppresses the metastasis of clear cell renal cell carcinoma through ROS scavenging |
| title_sort | astaxanthin suppresses the metastasis of clear cell renal cell carcinoma through ros scavenging |
| topic | Clear cell renal cell carcinoma ROS Astaxanthin Metastasis |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624001415 |
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