Flavonoids as dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and in vitro studies

Flavonoids as dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and in vitro studies

Abstract Background Inflammation is known to involve in many pathological processes of different diseases, but the current therapy causes adverse effects. Thus, there is a great interest for the discovery of flavonoids as a valuable alternative to classical analgesic and anti-inflammatory agent with...

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Bibliographic Details
Main Authors: Muhd Hanis Md Idris, Siti Norhidayu Mohd Amin, Siti Norhidayah Mohd Amin, Nyotia Nyokat, Heng Yen Khong, Manikandan Selvaraj, Zainul Amiruddin Zakaria, Zurina Shaameri, Ahmad Sazali Hamzah, Lay Kek Teh, Mohd Zaki Salleh
Format: Article
Language:English
Published: SpringerOpen 2022-09-01
Series:Beni-Suef University Journal of Basic and Applied Sciences
Subjects:
Arachidonic acid
Inflammation
Chalcone
Flavone
Flavanone
Online Access:https://doi.org/10.1186/s43088-022-00296-y

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