PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.

PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases affecting photoreceptors and causing blindness in humans. Previously, excessive activation of enzymes belonging to the poly-ADP-ribose polymerase (PARP) group was shown to be involved in photoreceptor degeneration in the hu...

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Main Authors: Ayse Sahaboglu, Naoyuki Tanimoto, Jasvir Kaur, Javier Sancho-Pelluz, Gesine Huber, Edda Fahl, Blanca Arango-Gonzalez, Eberhart Zrenner, Per Ekström, Hubert Löwenheim, Mathias Seeliger, François Paquet-Durand
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2990765?pdf=render

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