A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream
Abstract Plants used in traditional medicine offer an affordable new alternative in tissue repair therapy. This study aimed to evaluate the effectiveness of the 5% Rhizophora mangle cream compared to the 5% dexpanthenol cream in healing open surgical wounds on the upper eyelid. A total of 18 patient...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2024-04-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000100705&tlng=en |
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| author | JERRAR J.X. SILVA LEILA B. LEAL JÉSSICA G.A. SÁ LARISSA R.A. SABINO ISABELLE M.F.S.D. CAVALCANTI LUZIA A. SILVA EDUARDA S. DE SANTANA FERNANDO HENRIQUE P. FERNANDES IRANILDO JOSÉ C. FILHO WESLEY F.M. BRANDÃO JEYMESSON RAPHAEL C. VIEIRA |
| author_facet | JERRAR J.X. SILVA LEILA B. LEAL JÉSSICA G.A. SÁ LARISSA R.A. SABINO ISABELLE M.F.S.D. CAVALCANTI LUZIA A. SILVA EDUARDA S. DE SANTANA FERNANDO HENRIQUE P. FERNANDES IRANILDO JOSÉ C. FILHO WESLEY F.M. BRANDÃO JEYMESSON RAPHAEL C. VIEIRA |
| author_sort | JERRAR J.X. SILVA |
| collection | DOAJ |
| description | Abstract Plants used in traditional medicine offer an affordable new alternative in tissue repair therapy. This study aimed to evaluate the effectiveness of the 5% Rhizophora mangle cream compared to the 5% dexpanthenol cream in healing open surgical wounds on the upper eyelid. A total of 18 patients were submitted to the experiment and divided into 2 groups with 9 patients each who used topically and daily 5% dexpanthenol cream (control group) or 5% R.mangle cream (intervention group) for 7 days. Clinical, morphometric and histomorphometric analyses of wounds and surgical procedures for skin removal were performed. In the morphometric analysis, all wounds treated with R.mangle and dexpanthenol creams showed complete macroscopic scars, without inflammatory signs and infection free. The skin hydration values in pre and post application periods of the cream were 43.82 ± 43.93 and 62.12 ± 67.40 respectively. The histomorphometric study showed lower values of epithelium distance in R. mangle group and higher in dexpanthenol group with significant difference between groups (p < 0.05). The R.mangle 5% cream proved to be effective in healing wounds of human upper eyelid skin with a significant improvement in epithelization compared to dexpanthenol 5% cream. |
| first_indexed | 2024-04-24T11:51:24Z |
| format | Article |
| id | doaj.art-9626e4b1388143dab0df7bc0f354c75c |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-24T11:51:24Z |
| publishDate | 2024-04-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-9626e4b1388143dab0df7bc0f354c75c2024-04-09T07:42:02ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902024-04-0196110.1590/0001-3765202420231143A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based creamJERRAR J.X. SILVAhttps://orcid.org/0000-0003-4237-5321LEILA B. LEALhttps://orcid.org/0000-0003-3017-9120JÉSSICA G.A. SÁhttps://orcid.org/0000-0002-3663-5572LARISSA R.A. SABINOhttps://orcid.org/0000-0001-5875-4911ISABELLE M.F.S.D. CAVALCANTIhttps://orcid.org/0000-0002-3023-7311LUZIA A. SILVAhttps://orcid.org/0000-0002-8623-3045EDUARDA S. DE SANTANAhttps://orcid.org/0000-0002-9019-6072FERNANDO HENRIQUE P. FERNANDEShttps://orcid.org/0000-0002-5207-7937IRANILDO JOSÉ C. FILHOhttps://orcid.org/0000-0002-5466-6567WESLEY F.M. BRANDÃOhttps://orcid.org/0000-0002-8521-8863JEYMESSON RAPHAEL C. VIEIRAhttps://orcid.org/0000-0003-3793-5830Abstract Plants used in traditional medicine offer an affordable new alternative in tissue repair therapy. This study aimed to evaluate the effectiveness of the 5% Rhizophora mangle cream compared to the 5% dexpanthenol cream in healing open surgical wounds on the upper eyelid. A total of 18 patients were submitted to the experiment and divided into 2 groups with 9 patients each who used topically and daily 5% dexpanthenol cream (control group) or 5% R.mangle cream (intervention group) for 7 days. Clinical, morphometric and histomorphometric analyses of wounds and surgical procedures for skin removal were performed. In the morphometric analysis, all wounds treated with R.mangle and dexpanthenol creams showed complete macroscopic scars, without inflammatory signs and infection free. The skin hydration values in pre and post application periods of the cream were 43.82 ± 43.93 and 62.12 ± 67.40 respectively. The histomorphometric study showed lower values of epithelium distance in R. mangle group and higher in dexpanthenol group with significant difference between groups (p < 0.05). The R.mangle 5% cream proved to be effective in healing wounds of human upper eyelid skin with a significant improvement in epithelization compared to dexpanthenol 5% cream.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000100705&tlng=enWound healingRhizophoraceaePhytotherapyMangroveCream |
| spellingShingle | JERRAR J.X. SILVA LEILA B. LEAL JÉSSICA G.A. SÁ LARISSA R.A. SABINO ISABELLE M.F.S.D. CAVALCANTI LUZIA A. SILVA EDUARDA S. DE SANTANA FERNANDO HENRIQUE P. FERNANDES IRANILDO JOSÉ C. FILHO WESLEY F.M. BRANDÃO JEYMESSON RAPHAEL C. VIEIRA A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream Anais da Academia Brasileira de Ciências Wound healing Rhizophoraceae Phytotherapy Mangrove Cream |
| title | A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream |
| title_full | A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream |
| title_fullStr | A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream |
| title_full_unstemmed | A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream |
| title_short | A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream |
| title_sort | preliminary study of cutaneous wound healing on the upper eyelid in a small brazilian population using rhizophora mangle based cream |
| topic | Wound healing Rhizophoraceae Phytotherapy Mangrove Cream |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000100705&tlng=en |
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