Synbiotics use for preventing sepsis and necrotizing enterocolitis in very low birth weight neonates: a randomized controlled trial
Background Probiotics and prebiotics have strain-specific effects on the host. Synbiotics, a mixture of probiotics and prebiotics, are proposed to have more beneficial effects on the host than either agent has alone. Purpose We performed a randomized controlled trial to investigate the effect of Lac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2020-06-01
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| Series: | Clinical and Experimental Pediatrics |
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| Online Access: | http://www.e-cep.org/upload/pdf/cep-2019-00381.pdf |
| _version_ | 1818521476548001792 |
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| author | Ozge Serce Pehlevan Derya Benzer Tugba Gursoy Guner Karatekin Fahri Ovali |
| author_facet | Ozge Serce Pehlevan Derya Benzer Tugba Gursoy Guner Karatekin Fahri Ovali |
| author_sort | Ozge Serce Pehlevan |
| collection | DOAJ |
| description | Background Probiotics and prebiotics have strain-specific effects on the host. Synbiotics, a mixture of probiotics and prebiotics, are proposed to have more beneficial effects on the host than either agent has alone. Purpose We performed a randomized controlled trial to investigate the effect of Lactobacillus and Bifidobacterium together with oligosaccharides and lactoferrin on the development of necrotizing enterocolitis (NEC) or sepsis in very low birth weight neonates. Methods Neonates with a gestational age ≤32 weeks and birth weight ≤1,500 g were enrolled. The study group received a combination of synbiotics and lactoferrin, whereas the control group received 1 mL of distilled water as placebo starting with the first feed until discharge. The outcome measures were the incidence of NEC stage ≥2 or late-onset cultureproven sepsis and NEC stage ≥2 or death. Results Mean birth weight and gestational age of the study (n=104) and the control (n=104) groups were 1,197±235 g vs. 1,151±269 g and 29±1.9 vs. 28±2.2 weeks, respectively (P>0.05). Neither the incidence of NEC stage ≥2 or death, nor the incidence of NEC stage ≥2 or late-onset culture-proven sepsis differed between the study and control groups (5.8% vs. 5.9%, P=1; 26% vs. 21.2%, P=0.51). The only significant difference was the incidence of all stages of NEC (1.9% vs. 10.6%, P=0.019). Conclusion The combination of synbiotics and lactoferrin did not reduce NEC severity, sepsis, or mortality. |
| first_indexed | 2024-12-11T01:51:29Z |
| format | Article |
| id | doaj.art-9627e3cd80794f8ba2296555291be66e |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-12-11T01:51:29Z |
| publishDate | 2020-06-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-9627e3cd80794f8ba2296555291be66e2022-12-22T01:24:43ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482020-06-0163622623110.3345/cep.2019.0038120125553620Synbiotics use for preventing sepsis and necrotizing enterocolitis in very low birth weight neonates: a randomized controlled trialOzge Serce Pehlevan0Derya Benzer1Tugba Gursoy2Guner Karatekin3Fahri Ovali4 Neonatology Unit, Zeynep Kamil Maternity and Children’s Training and Research Hospital, University of Health Sciences, Istanbul, Turkey Neonatology Unit, Zeynep Kamil Maternity and Children’s Training and Research Hospital, University of Health Sciences, Istanbul, Turkey Neonatology Unit, Koc University School of Medicine, Istanbul, Turkey Neonatology Unit, Zeynep Kamil Maternity and Children’s Training and Research Hospital, University of Health Sciences, Istanbul, Turkey Neonatology Unit, Zeynep Kamil Maternity and Children’s Training and Research Hospital, University of Health Sciences, Istanbul, TurkeyBackground Probiotics and prebiotics have strain-specific effects on the host. Synbiotics, a mixture of probiotics and prebiotics, are proposed to have more beneficial effects on the host than either agent has alone. Purpose We performed a randomized controlled trial to investigate the effect of Lactobacillus and Bifidobacterium together with oligosaccharides and lactoferrin on the development of necrotizing enterocolitis (NEC) or sepsis in very low birth weight neonates. Methods Neonates with a gestational age ≤32 weeks and birth weight ≤1,500 g were enrolled. The study group received a combination of synbiotics and lactoferrin, whereas the control group received 1 mL of distilled water as placebo starting with the first feed until discharge. The outcome measures were the incidence of NEC stage ≥2 or late-onset cultureproven sepsis and NEC stage ≥2 or death. Results Mean birth weight and gestational age of the study (n=104) and the control (n=104) groups were 1,197±235 g vs. 1,151±269 g and 29±1.9 vs. 28±2.2 weeks, respectively (P>0.05). Neither the incidence of NEC stage ≥2 or death, nor the incidence of NEC stage ≥2 or late-onset culture-proven sepsis differed between the study and control groups (5.8% vs. 5.9%, P=1; 26% vs. 21.2%, P=0.51). The only significant difference was the incidence of all stages of NEC (1.9% vs. 10.6%, P=0.019). Conclusion The combination of synbiotics and lactoferrin did not reduce NEC severity, sepsis, or mortality.http://www.e-cep.org/upload/pdf/cep-2019-00381.pdfnecrotizing enterocolitissepsissynbioticsvery low birth weight infant |
| spellingShingle | Ozge Serce Pehlevan Derya Benzer Tugba Gursoy Guner Karatekin Fahri Ovali Synbiotics use for preventing sepsis and necrotizing enterocolitis in very low birth weight neonates: a randomized controlled trial Clinical and Experimental Pediatrics necrotizing enterocolitis sepsis synbiotics very low birth weight infant |
| title | Synbiotics use for preventing sepsis and necrotizing enterocolitis in very low birth weight neonates: a randomized controlled trial |
| title_full | Synbiotics use for preventing sepsis and necrotizing enterocolitis in very low birth weight neonates: a randomized controlled trial |
| title_fullStr | Synbiotics use for preventing sepsis and necrotizing enterocolitis in very low birth weight neonates: a randomized controlled trial |
| title_full_unstemmed | Synbiotics use for preventing sepsis and necrotizing enterocolitis in very low birth weight neonates: a randomized controlled trial |
| title_short | Synbiotics use for preventing sepsis and necrotizing enterocolitis in very low birth weight neonates: a randomized controlled trial |
| title_sort | synbiotics use for preventing sepsis and necrotizing enterocolitis in very low birth weight neonates a randomized controlled trial |
| topic | necrotizing enterocolitis sepsis synbiotics very low birth weight infant |
| url | http://www.e-cep.org/upload/pdf/cep-2019-00381.pdf |
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