The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review
The PPARG gene has the great value in predicting of carbohydrate metabolism disorders development and the patients response to different therapy options. The article presents the information about the association between the single nucleotide polymorphism rs1801282 PPARG and the risk of different ca...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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ZAO "Consilium Medicum"
2022-06-01
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| Series: | Consilium Medicum |
| Subjects: | |
| Online Access: | https://consilium.orscience.ru/2075-1753/article/viewFile/108931/83044 |
| _version_ | 1811236130283061248 |
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| author | Kamilya B. Khasanova Maria S. Medvedeva Elena V. Valeeva Zhanna A. Rodygina Tatiana A. Kiseleva Farida V. Valeeva |
| author_facet | Kamilya B. Khasanova Maria S. Medvedeva Elena V. Valeeva Zhanna A. Rodygina Tatiana A. Kiseleva Farida V. Valeeva |
| author_sort | Kamilya B. Khasanova |
| collection | DOAJ |
| description | The PPARG gene has the great value in predicting of carbohydrate metabolism disorders development and the patients response to different therapy options. The article presents the information about the association between the single nucleotide polymorphism rs1801282 PPARG and the risk of different carbohydrate metabolism disorders development based on a review of the domestic and foreign researches. Despite that literature data regarding the association of this polymorphism with the development of metabolic disorders differ, most researchers agree that the G-allele of rs1801282 PPARG has the protective effect in relation to the risk of carbohydrate metabolism disorders development. The particular emphasis is placed on the association of rs1801282 PPARG with the results of carbohydrate metabolism disorders management, taking into account the lifestyle changes as well as the intake of oral hypoglycemic drugs used in the treatment of prediabetes and type 2 diabetes. Thus, a number of studies have shown that the G-allele carriers of rs1801282 PPARG had a better response to pioglitazone treatment in the form of lowering of fasting glucose and A1C levels and lipid profile normalization. The association of the polymorphism with the results of therapy with metformin remains an open question that requires further study. |
| first_indexed | 2024-04-12T12:03:38Z |
| format | Article |
| id | doaj.art-962859d8eb144b0db4aa97063cd7e56f |
| institution | Directory Open Access Journal |
| issn | 2075-1753 2542-2170 |
| language | Russian |
| last_indexed | 2024-04-12T12:03:38Z |
| publishDate | 2022-06-01 |
| publisher | ZAO "Consilium Medicum" |
| record_format | Article |
| series | Consilium Medicum |
| spelling | doaj.art-962859d8eb144b0db4aa97063cd7e56f2022-12-22T03:33:46ZrusZAO "Consilium Medicum"Consilium Medicum2075-17532542-21702022-06-0124426627010.26442/20751753.2022.4.2016724562The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A reviewKamilya B. Khasanova0https://orcid.org/0000-0003-1825-487XMaria S. Medvedeva1https://orcid.org/0000-0001-8891-5114Elena V. Valeeva2https://orcid.org/0000-0001-7080-3878Zhanna A. Rodygina3https://orcid.org/0000-0002-1916-1336Tatiana A. Kiseleva4https://orcid.org/0000-0001-8959-093XFarida V. Valeeva5https://orcid.org/0000-0001-6000-8002Kazan State Medical UniversityKazan State Medical UniversityKazan State Medical UniversityKazan State Medical UniversityKazan State Medical UniversityKazan State Medical UniversityThe PPARG gene has the great value in predicting of carbohydrate metabolism disorders development and the patients response to different therapy options. The article presents the information about the association between the single nucleotide polymorphism rs1801282 PPARG and the risk of different carbohydrate metabolism disorders development based on a review of the domestic and foreign researches. Despite that literature data regarding the association of this polymorphism with the development of metabolic disorders differ, most researchers agree that the G-allele of rs1801282 PPARG has the protective effect in relation to the risk of carbohydrate metabolism disorders development. The particular emphasis is placed on the association of rs1801282 PPARG with the results of carbohydrate metabolism disorders management, taking into account the lifestyle changes as well as the intake of oral hypoglycemic drugs used in the treatment of prediabetes and type 2 diabetes. Thus, a number of studies have shown that the G-allele carriers of rs1801282 PPARG had a better response to pioglitazone treatment in the form of lowering of fasting glucose and A1C levels and lipid profile normalization. The association of the polymorphism with the results of therapy with metformin remains an open question that requires further study.https://consilium.orscience.ru/2075-1753/article/viewFile/108931/83044ppargpolymorphismcarbohydrate metabolismtype 2 diabeteslifestylepharmacogenetics |
| spellingShingle | Kamilya B. Khasanova Maria S. Medvedeva Elena V. Valeeva Zhanna A. Rodygina Tatiana A. Kiseleva Farida V. Valeeva The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review Consilium Medicum pparg polymorphism carbohydrate metabolism type 2 diabetes lifestyle pharmacogenetics |
| title | The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review |
| title_full | The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review |
| title_fullStr | The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review |
| title_full_unstemmed | The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review |
| title_short | The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review |
| title_sort | role of the rs1801282 pparg polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management a review |
| topic | pparg polymorphism carbohydrate metabolism type 2 diabetes lifestyle pharmacogenetics |
| url | https://consilium.orscience.ru/2075-1753/article/viewFile/108931/83044 |
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