Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers
Transcription factors encoded by <i>Homeobox</i> (<i>HOX</i>) genes play numerous key functions during early embryonic development and differentiation. Multiple reports have shown that mis-regulation of <i>HOX</i> gene expression plays key roles in the development...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/6/1572 |
| _version_ | 1797565376104497152 |
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| author | Orit Adato Yaron Orenstein Juri Kopolovic Tamar Juven-Gershon Ron Unger |
| author_facet | Orit Adato Yaron Orenstein Juri Kopolovic Tamar Juven-Gershon Ron Unger |
| author_sort | Orit Adato |
| collection | DOAJ |
| description | Transcription factors encoded by <i>Homeobox</i> (<i>HOX</i>) genes play numerous key functions during early embryonic development and differentiation. Multiple reports have shown that mis-regulation of <i>HOX</i> gene expression plays key roles in the development of cancers. Their expression levels in cancers tend to differ based on tissue and tumor type. Here, we performed a comprehensive analysis comparing <i>HOX</i> gene expression in different cancer types, obtained from The Cancer Genome Atlas (TCGA), with matched healthy tissues, obtained from Genotype-Tissue Expression (GTEx). We identified and quantified differential expression patterns that confirmed previously identified expression changes and highlighted new differential expression signatures. We discovered differential expression patterns that are in line with patient survival data. This comprehensive and quantitative analysis provides a global picture of <i>HOX</i> genes’ differential expression patterns in different cancer types. |
| first_indexed | 2024-03-10T19:11:16Z |
| format | Article |
| id | doaj.art-962ad099ff5245a5b9463e51f2aef5da |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:11:16Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-962ad099ff5245a5b9463e51f2aef5da2023-11-20T03:47:00ZengMDPI AGCancers2072-66942020-06-01126157210.3390/cancers12061572Quantitative Analysis of Differential Expression of HOX Genes in Multiple CancersOrit Adato0Yaron Orenstein1Juri Kopolovic2Tamar Juven-Gershon3Ron Unger4The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, IsraelSchool of Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, IsraelDepartment of Pathology, Hadassah Medical Center, Jerusalem 9112102, IsraelThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, IsraelThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, IsraelTranscription factors encoded by <i>Homeobox</i> (<i>HOX</i>) genes play numerous key functions during early embryonic development and differentiation. Multiple reports have shown that mis-regulation of <i>HOX</i> gene expression plays key roles in the development of cancers. Their expression levels in cancers tend to differ based on tissue and tumor type. Here, we performed a comprehensive analysis comparing <i>HOX</i> gene expression in different cancer types, obtained from The Cancer Genome Atlas (TCGA), with matched healthy tissues, obtained from Genotype-Tissue Expression (GTEx). We identified and quantified differential expression patterns that confirmed previously identified expression changes and highlighted new differential expression signatures. We discovered differential expression patterns that are in line with patient survival data. This comprehensive and quantitative analysis provides a global picture of <i>HOX</i> genes’ differential expression patterns in different cancer types.https://www.mdpi.com/2072-6694/12/6/1572<i>HOX</i> genescancertranscription factorsdifferential expression analysispatient survival |
| spellingShingle | Orit Adato Yaron Orenstein Juri Kopolovic Tamar Juven-Gershon Ron Unger Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers Cancers <i>HOX</i> genes cancer transcription factors differential expression analysis patient survival |
| title | Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers |
| title_full | Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers |
| title_fullStr | Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers |
| title_full_unstemmed | Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers |
| title_short | Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers |
| title_sort | quantitative analysis of differential expression of hox genes in multiple cancers |
| topic | <i>HOX</i> genes cancer transcription factors differential expression analysis patient survival |
| url | https://www.mdpi.com/2072-6694/12/6/1572 |
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