Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation
Block copolymer dispersions that form gels at body temperature and that additionally are able to reduce a gold salt to nanoparticles (AuNPs) directly in the final formulation under mild conditions were designed as hybrid depots for photothermal therapy. The in situ gelling systems may retain AuNPs i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/2/52 |
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| author | Sonia Cabana-Montenegro Silvia Barbosa Pablo Taboada Angel Concheiro Carmen Alvarez-Lorenzo |
| author_facet | Sonia Cabana-Montenegro Silvia Barbosa Pablo Taboada Angel Concheiro Carmen Alvarez-Lorenzo |
| author_sort | Sonia Cabana-Montenegro |
| collection | DOAJ |
| description | Block copolymer dispersions that form gels at body temperature and that additionally are able to reduce a gold salt to nanoparticles (AuNPs) directly in the final formulation under mild conditions were designed as hybrid depots for photothermal therapy. The in situ gelling systems may retain AuNPs in the application zone for a long time so that localized elevations of temperature can be achieved each time the zone is irradiated. To carry out the work, dispersions were prepared covering a wide range of poloxamine Tetronic 1307:gold salt molar ratios in NaCl media (also varying from pure water to hypertonic solution). Even at copolymer concentrations well above the critical micelle concentration, the reducing power of the copolymer was maintained, and AuNPs were formed in few hours without extra additives. Varying the copolymer and NaCl concentrations allowed a fine tuning of nanoparticles’ shape from spherical to triangular nanoplates, which determined that the surface plasmon resonance showed a maximum intensity at 540 nm or at 1000 nm, respectively. The information gathered on the effects of (i) the poloxamine concentration on AuNPs’ size and shape under isotonic conditions, (ii) the AuNPs on the temperature-induced gelling transition, and (iii) the gel properties on the photothermal responsiveness of the AuNPs during successive irradiation cycles may help the rational design of one-pot gels with built-in temperature and light responsiveness. |
| first_indexed | 2024-04-11T11:14:15Z |
| format | Article |
| id | doaj.art-962c071b708d47e889e81fb7ee642955 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T11:14:15Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-962c071b708d47e889e81fb7ee6429552022-12-22T04:27:19ZengMDPI AGPharmaceutics1999-49232019-01-011125210.3390/pharmaceutics11020052pharmaceutics11020052Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal AblationSonia Cabana-Montenegro0Silvia Barbosa1Pablo Taboada2Angel Concheiro3Carmen Alvarez-Lorenzo4Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainÁrea de Física de la Materia Condensada, Facultad de Física, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainÁrea de Física de la Materia Condensada, Facultad de Física, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainBlock copolymer dispersions that form gels at body temperature and that additionally are able to reduce a gold salt to nanoparticles (AuNPs) directly in the final formulation under mild conditions were designed as hybrid depots for photothermal therapy. The in situ gelling systems may retain AuNPs in the application zone for a long time so that localized elevations of temperature can be achieved each time the zone is irradiated. To carry out the work, dispersions were prepared covering a wide range of poloxamine Tetronic 1307:gold salt molar ratios in NaCl media (also varying from pure water to hypertonic solution). Even at copolymer concentrations well above the critical micelle concentration, the reducing power of the copolymer was maintained, and AuNPs were formed in few hours without extra additives. Varying the copolymer and NaCl concentrations allowed a fine tuning of nanoparticles’ shape from spherical to triangular nanoplates, which determined that the surface plasmon resonance showed a maximum intensity at 540 nm or at 1000 nm, respectively. The information gathered on the effects of (i) the poloxamine concentration on AuNPs’ size and shape under isotonic conditions, (ii) the AuNPs on the temperature-induced gelling transition, and (iii) the gel properties on the photothermal responsiveness of the AuNPs during successive irradiation cycles may help the rational design of one-pot gels with built-in temperature and light responsiveness.https://www.mdpi.com/1999-4923/11/2/52in situ gelling systemsphoto-thermal therapygold reductionlocalized heating effectirradiation cyclessyringeable implant |
| spellingShingle | Sonia Cabana-Montenegro Silvia Barbosa Pablo Taboada Angel Concheiro Carmen Alvarez-Lorenzo Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation Pharmaceutics in situ gelling systems photo-thermal therapy gold reduction localized heating effect irradiation cycles syringeable implant |
| title | Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation |
| title_full | Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation |
| title_fullStr | Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation |
| title_full_unstemmed | Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation |
| title_short | Syringeable Self-Organizing Gels that Trigger Gold Nanoparticle Formation for Localized Thermal Ablation |
| title_sort | syringeable self organizing gels that trigger gold nanoparticle formation for localized thermal ablation |
| topic | in situ gelling systems photo-thermal therapy gold reduction localized heating effect irradiation cycles syringeable implant |
| url | https://www.mdpi.com/1999-4923/11/2/52 |
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