Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches
A bidirectional causal relationship has been established between temporomandibular disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic pain offer a framework for understanding the comorbidity between these two conditions that might reside in the shared biomolecular...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/15/12200 |
| _version_ | 1797586689549402112 |
|---|---|
| author | Linda Sangalli Bradley Eli Sachi Mehrotra Suzan Sabagh James Fricton |
| author_facet | Linda Sangalli Bradley Eli Sachi Mehrotra Suzan Sabagh James Fricton |
| author_sort | Linda Sangalli |
| collection | DOAJ |
| description | A bidirectional causal relationship has been established between temporomandibular disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic pain offer a framework for understanding the comorbidity between these two conditions that might reside in the shared biomolecular mechanisms of peripheral and central sensitization. The initiation of these processes is inflammatory in nature and is most likely mediated by key molecules, including calcitonin gene-related peptide (CGRP). This scoping review proposes that CGRP-mediated neuroinflammation in the trigeminal ganglion may partly explain the biomolecular bidirectional link between TMDs and chronic headaches. Finally, clinical implications of this neuropathologic process are briefly discussed. |
| first_indexed | 2024-03-11T00:25:37Z |
| format | Article |
| id | doaj.art-962d256814fd4d6c8bf605909196779c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:25:37Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-962d256814fd4d6c8bf605909196779c2023-11-18T23:01:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124151220010.3390/ijms241512200Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic HeadachesLinda Sangalli0Bradley Eli1Sachi Mehrotra2Suzan Sabagh3James Fricton4College of Dental Medicine—Illinois, Midwestern University, Downers Grove, IL 60515, USAFacial Pain Specialists, San Diego, CA 92121,USAFacial Pain Specialists, San Diego, CA 92121,USAFacial Pain Specialists, San Diego, CA 92121,USADivision of TMD and Orofacial Pain, University of Minnesota Schoof of Dentistry, Minneapolis, MN 55455, USAA bidirectional causal relationship has been established between temporomandibular disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic pain offer a framework for understanding the comorbidity between these two conditions that might reside in the shared biomolecular mechanisms of peripheral and central sensitization. The initiation of these processes is inflammatory in nature and is most likely mediated by key molecules, including calcitonin gene-related peptide (CGRP). This scoping review proposes that CGRP-mediated neuroinflammation in the trigeminal ganglion may partly explain the biomolecular bidirectional link between TMDs and chronic headaches. Finally, clinical implications of this neuropathologic process are briefly discussed.https://www.mdpi.com/1422-0067/24/15/12200temporomandibular disordersheadachemigrainecentral sensitizationcalcitonin gene-related peptide |
| spellingShingle | Linda Sangalli Bradley Eli Sachi Mehrotra Suzan Sabagh James Fricton Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches International Journal of Molecular Sciences temporomandibular disorders headache migraine central sensitization calcitonin gene-related peptide |
| title | Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches |
| title_full | Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches |
| title_fullStr | Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches |
| title_full_unstemmed | Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches |
| title_short | Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches |
| title_sort | calcitonin gene related peptide mediated trigeminal ganglionitis the biomolecular link between temporomandibular disorders and chronic headaches |
| topic | temporomandibular disorders headache migraine central sensitization calcitonin gene-related peptide |
| url | https://www.mdpi.com/1422-0067/24/15/12200 |
| work_keys_str_mv | AT lindasangalli calcitoningenerelatedpeptidemediatedtrigeminalganglionitisthebiomolecularlinkbetweentemporomandibulardisordersandchronicheadaches AT bradleyeli calcitoningenerelatedpeptidemediatedtrigeminalganglionitisthebiomolecularlinkbetweentemporomandibulardisordersandchronicheadaches AT sachimehrotra calcitoningenerelatedpeptidemediatedtrigeminalganglionitisthebiomolecularlinkbetweentemporomandibulardisordersandchronicheadaches AT suzansabagh calcitoningenerelatedpeptidemediatedtrigeminalganglionitisthebiomolecularlinkbetweentemporomandibulardisordersandchronicheadaches AT jamesfricton calcitoningenerelatedpeptidemediatedtrigeminalganglionitisthebiomolecularlinkbetweentemporomandibulardisordersandchronicheadaches |