PRDM16 Upregulation Induced by MicroRNA-448 Inhibition Alleviates Atherosclerosis via the TGF-β Signaling Pathway Inactivation

PRDM16 Upregulation Induced by MicroRNA-448 Inhibition Alleviates Atherosclerosis via the TGF-β Signaling Pathway Inactivation

The dysregulated expression of microRNAs (miRs) has been associated with pathological and physiological processes of atherosclerosis (AS). In addition, PR domain-containing 16 (PRDM16), a transcriptional mediator of brown fat cell identity and smooth muscle cell activities, may be involved in the hy...

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Bibliographic Details
Main Authors: Dongxing Liu, Jiantao Song, Xianfei Ji, Zunqi Liu, Tao Li, Bo Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Physiology
Subjects:
microRNA-448
PR domain-containing 16
atherosclerosis
proliferation
apoptosis
migration
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00846/full

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