Negative Symptoms and Behavioral Alterations Associated with Dorsolateral Prefrontal Syndrome in Patients with Schizophrenia
The present study had three main aims: (1) to explore the possible relationships between the two dimensions of negative symptoms (NS) with the three frontal behavioral syndromes (dorsolateral, orbitofrontal and the anterior or mesial cingulate circuit) in patients with schizophrenia; (2) to determin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/15/3417 |
| _version_ | 1797525459433422848 |
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| author | Pamela Ruiz-Castañeda María Teresa Daza-González Encarnación Santiago-Molina |
| author_facet | Pamela Ruiz-Castañeda María Teresa Daza-González Encarnación Santiago-Molina |
| author_sort | Pamela Ruiz-Castañeda |
| collection | DOAJ |
| description | The present study had three main aims: (1) to explore the possible relationships between the two dimensions of negative symptoms (NS) with the three frontal behavioral syndromes (dorsolateral, orbitofrontal and the anterior or mesial cingulate circuit) in patients with schizophrenia; (2) to determine the influence of sociodemographic and clinical variables on the severity of the two dimensions of NS (expressive deficits and disordered relationships/avolition); and (3) to explore the possible relationships between the two dimensions of NS and social functioning. We evaluated a group of 33 patients with schizophrenia with a predominance of NS using the self-reported version of the Frontal System Behavior scale. To quantify the severity of NS, the Assessment of Negative Symptoms (SANS) scale was used. The results revealed that the two dimensions of NS correlate positively with the behavioral syndrome of dorsolateral prefrontal origin. Regarding the influence of sociodemographic and clinical variables, in patients with a long evolution the NS of the expressive deficits dimension were less severe than in patients with a short evolution. A negative correlation was found between the severity of NS of the disordered relationships/avolition dimension and perceived social functioning. Our results show the importance of differentiating between the two dimensions of NS to characterize better their possible frontal etiology and impact on clinical course and social functioning. |
| first_indexed | 2024-03-10T09:13:08Z |
| format | Article |
| id | doaj.art-962e816b07464de4ba55c6988e8ca983 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:13:08Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-962e816b07464de4ba55c6988e8ca9832023-11-22T05:50:33ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011015341710.3390/jcm10153417Negative Symptoms and Behavioral Alterations Associated with Dorsolateral Prefrontal Syndrome in Patients with SchizophreniaPamela Ruiz-Castañeda0María Teresa Daza-González1Encarnación Santiago-Molina2Neuropsychological Evaluation and Rehabilitation Center (CERNEP), University of Almeria, Carretera de Sacramento, s/n, La Cañada de San Urbano, 04120 Almeria, SpainNeuropsychological Evaluation and Rehabilitation Center (CERNEP), University of Almeria, Carretera de Sacramento, s/n, La Cañada de San Urbano, 04120 Almeria, SpainMental Health Hospitalization Unit of Torrecárdenas Hospital, Calle Hermandad de Donantes de Sangre, s/n, 04009 Almería, SpainThe present study had three main aims: (1) to explore the possible relationships between the two dimensions of negative symptoms (NS) with the three frontal behavioral syndromes (dorsolateral, orbitofrontal and the anterior or mesial cingulate circuit) in patients with schizophrenia; (2) to determine the influence of sociodemographic and clinical variables on the severity of the two dimensions of NS (expressive deficits and disordered relationships/avolition); and (3) to explore the possible relationships between the two dimensions of NS and social functioning. We evaluated a group of 33 patients with schizophrenia with a predominance of NS using the self-reported version of the Frontal System Behavior scale. To quantify the severity of NS, the Assessment of Negative Symptoms (SANS) scale was used. The results revealed that the two dimensions of NS correlate positively with the behavioral syndrome of dorsolateral prefrontal origin. Regarding the influence of sociodemographic and clinical variables, in patients with a long evolution the NS of the expressive deficits dimension were less severe than in patients with a short evolution. A negative correlation was found between the severity of NS of the disordered relationships/avolition dimension and perceived social functioning. Our results show the importance of differentiating between the two dimensions of NS to characterize better their possible frontal etiology and impact on clinical course and social functioning.https://www.mdpi.com/2077-0383/10/15/3417schizophrenianegative symptomsfronto-subcortical syndromessocial functioning |
| spellingShingle | Pamela Ruiz-Castañeda María Teresa Daza-González Encarnación Santiago-Molina Negative Symptoms and Behavioral Alterations Associated with Dorsolateral Prefrontal Syndrome in Patients with Schizophrenia Journal of Clinical Medicine schizophrenia negative symptoms fronto-subcortical syndromes social functioning |
| title | Negative Symptoms and Behavioral Alterations Associated with Dorsolateral Prefrontal Syndrome in Patients with Schizophrenia |
| title_full | Negative Symptoms and Behavioral Alterations Associated with Dorsolateral Prefrontal Syndrome in Patients with Schizophrenia |
| title_fullStr | Negative Symptoms and Behavioral Alterations Associated with Dorsolateral Prefrontal Syndrome in Patients with Schizophrenia |
| title_full_unstemmed | Negative Symptoms and Behavioral Alterations Associated with Dorsolateral Prefrontal Syndrome in Patients with Schizophrenia |
| title_short | Negative Symptoms and Behavioral Alterations Associated with Dorsolateral Prefrontal Syndrome in Patients with Schizophrenia |
| title_sort | negative symptoms and behavioral alterations associated with dorsolateral prefrontal syndrome in patients with schizophrenia |
| topic | schizophrenia negative symptoms fronto-subcortical syndromes social functioning |
| url | https://www.mdpi.com/2077-0383/10/15/3417 |
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