Broccoli-Derived Glucoraphanin Activates AMPK/PGC1α/NRF2 Pathway and Ameliorates Dextran-Sulphate-Sodium-Induced Colitis in Mice

Broccoli-Derived Glucoraphanin Activates AMPK/PGC1α/NRF2 Pathway and Ameliorates Dextran-Sulphate-Sodium-Induced Colitis in Mice

As the prevalence of inflammatory bowel diseases (IBD) rises, the etiology of IBD draws increasing attention. Glucoraphanin (GRP), enriched in cruciferous vegetables, is a precursor of sulforaphane, known to have anti-inflammatory and antioxidative effects. We hypothesized that dietary GRP supplemen...

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Bibliographic Details
Main Authors: Qiyu Tian, Zhixin Xu, Qi Sun, Alejandro Bravo Iniguez, Min Du, Mei-Jun Zhu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antioxidants
Subjects:
glucoraphanin
inflammatory bowel diseases
DSS
NRF2
oxidative stress
mitochondrial homeostasis
Online Access:https://www.mdpi.com/2076-3921/11/12/2404

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