Function of MicroRNAs in Normal and Abnormal Ovarian Activities: A Review Focus on MicroRNA-21
Abstract:Some failures in ovary function, like folliculogenesis and oogenesis, can give rise to various infertility-associated problems, including polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI). PCOS influences 8 to 20% of women; while POI occurs in at least 1% of all wom...
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| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2024-04-01
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| Series: | International Journal of Fertility and Sterility |
| Subjects: | |
| Online Access: | https://www.ijfs.ir/article_706345_e714afe74f6f3c52548f1427a5ad9e54.pdf |
| _version_ | 1797303603060277248 |
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| author | Reza Arefnezhad Hossein Roghani-Shahraki Hossein Motedayyen Fatemeh Rezaei Tazangi |
| author_facet | Reza Arefnezhad Hossein Roghani-Shahraki Hossein Motedayyen Fatemeh Rezaei Tazangi |
| author_sort | Reza Arefnezhad |
| collection | DOAJ |
| description | Abstract:Some failures in ovary function, like folliculogenesis and oogenesis, can give rise to various infertility-associated problems, including polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI). PCOS influences 8 to 20% of women; while POI occurs in at least 1% of all women. Regrettably, the current therapies for these diseaseshave not sufficiently been effective, and finding a suitable strategy is still a puzzle. One of the helpful strategies for managing and treating these disorders is understanding the contributing pathogenesis and mechanisms. Recently, it has been declared that abnormal expression of microRNAs (miRNAs), as a subset of non-coding RNAs, is involved in thepathogenesis of reproductive diseases. Among the miRNAs, the roles of miRNA-21 in the pathogenesis of PCOS and POI have been highlighted in some documents; hence, the purpose of this mini-review was to summarize the evidence in conjunction with the functions of this miRNA and other effective microRNAs in the normal or abnormal functions of the ovary (i.e., PCOS and POI) with a mechanistic insight. |
| first_indexed | 2024-03-07T23:55:04Z |
| format | Article |
| id | doaj.art-9631d72fbdfd4d6b8067cd7a2994318e |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-03-07T23:55:04Z |
| publishDate | 2024-04-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-9631d72fbdfd4d6b8067cd7a2994318e2024-02-18T08:39:20ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782024-04-01182949910.22074/ijfs.2023.1985792.1415706345Function of MicroRNAs in Normal and Abnormal Ovarian Activities: A Review Focus on MicroRNA-21Reza Arefnezhad0Hossein Roghani-Shahraki1Hossein Motedayyen2Fatemeh Rezaei Tazangi3Coenzyme R Research Institute, Tehran, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranAutoimmune Diseases Research Center, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, IranDepartment of Anatomy, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, IranAbstract:Some failures in ovary function, like folliculogenesis and oogenesis, can give rise to various infertility-associated problems, including polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI). PCOS influences 8 to 20% of women; while POI occurs in at least 1% of all women. Regrettably, the current therapies for these diseaseshave not sufficiently been effective, and finding a suitable strategy is still a puzzle. One of the helpful strategies for managing and treating these disorders is understanding the contributing pathogenesis and mechanisms. Recently, it has been declared that abnormal expression of microRNAs (miRNAs), as a subset of non-coding RNAs, is involved in thepathogenesis of reproductive diseases. Among the miRNAs, the roles of miRNA-21 in the pathogenesis of PCOS and POI have been highlighted in some documents; hence, the purpose of this mini-review was to summarize the evidence in conjunction with the functions of this miRNA and other effective microRNAs in the normal or abnormal functions of the ovary (i.e., PCOS and POI) with a mechanistic insight.https://www.ijfs.ir/article_706345_e714afe74f6f3c52548f1427a5ad9e54.pdfmicrorna-21pathogenesispolycystic ovarian syndromepremature ovarian insufficiency |
| spellingShingle | Reza Arefnezhad Hossein Roghani-Shahraki Hossein Motedayyen Fatemeh Rezaei Tazangi Function of MicroRNAs in Normal and Abnormal Ovarian Activities: A Review Focus on MicroRNA-21 International Journal of Fertility and Sterility microrna-21 pathogenesis polycystic ovarian syndrome premature ovarian insufficiency |
| title | Function of MicroRNAs in Normal and Abnormal Ovarian Activities: A Review Focus on MicroRNA-21 |
| title_full | Function of MicroRNAs in Normal and Abnormal Ovarian Activities: A Review Focus on MicroRNA-21 |
| title_fullStr | Function of MicroRNAs in Normal and Abnormal Ovarian Activities: A Review Focus on MicroRNA-21 |
| title_full_unstemmed | Function of MicroRNAs in Normal and Abnormal Ovarian Activities: A Review Focus on MicroRNA-21 |
| title_short | Function of MicroRNAs in Normal and Abnormal Ovarian Activities: A Review Focus on MicroRNA-21 |
| title_sort | function of micrornas in normal and abnormal ovarian activities a review focus on microrna 21 |
| topic | microrna-21 pathogenesis polycystic ovarian syndrome premature ovarian insufficiency |
| url | https://www.ijfs.ir/article_706345_e714afe74f6f3c52548f1427a5ad9e54.pdf |
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