Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty
ObjectivesThis study intended to explore whether albumin-associated inflammatory and nutritional markers could predict post-operative delirium (POD) in older patients after total hip arthroplasty (THA). In addition, we established a nomogram model for POD prediction.MethodsTotally, 254 elderly cases...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1158851/full |
| _version_ | 1797641693507354624 |
|---|---|
| author | Wenhao Hu Ziyi Song Houlai Shang Jingcheng Wang Yuedong Hao |
| author_facet | Wenhao Hu Ziyi Song Houlai Shang Jingcheng Wang Yuedong Hao |
| author_sort | Wenhao Hu |
| collection | DOAJ |
| description | ObjectivesThis study intended to explore whether albumin-associated inflammatory and nutritional markers could predict post-operative delirium (POD) in older patients after total hip arthroplasty (THA). In addition, we established a nomogram model for POD prediction.MethodsTotally, 254 elderly cases who received THA were included. Clinical and laboratory data of these patients were retrospectively collected. Albumin-associated inflammatory and nutritional markers included neutrophil-to-albumin ratio (NAR), CRP-to-albumin ratio (CAR), prognostic nutritional index (PNI), and systemic inflammation score (SIS). The LASSO, univariate and multivariate logistic regression analyses were utilized to screen risk factors. A nomogram model was developed according to the results of multivariate regression analyses.ResultsAmong 254 patients, 49 cases had POD with an incidence of 19.3%. LASSO regression and multivariate logistic analyses suggested that preoperative NAR, preoperative PNI, preoperative SIS, and age >75 years were risk factors for POD. A nomogram model was developed according to the results of multivariate logistic analyses. The calibration curve suggested that the predicted probability of this nomogram model was in good line with the actual probability. The DCA showed that this nomogram model had net benefits for the prediction of POD for elderly patients following THA.ConclusionAlbumin-associated inflammatory and nutritional markers including NAR, PNI, and SIS could predict POD in elderly patients following THA. |
| first_indexed | 2024-03-11T13:49:22Z |
| format | Article |
| id | doaj.art-9634b03bb0b5425795f3ebf3053195f1 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-11T13:49:22Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-9634b03bb0b5425795f3ebf3053195f12023-11-02T09:28:56ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-11-011010.3389/fnut.2023.11588511158851Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplastyWenhao Hu0Ziyi Song1Houlai Shang2Jingcheng Wang3Yuedong Hao4Department of Orthopedic Surgery, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaDepartment of Orthopedic Surgery, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaDepartment of Orthopedic Surgery, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaDepartment of Orthopedics, Subei People’s Hospital of Jiangsu Province, Yangzhou, Jiangsu, ChinaDepartment of Orthopedic Surgery, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaObjectivesThis study intended to explore whether albumin-associated inflammatory and nutritional markers could predict post-operative delirium (POD) in older patients after total hip arthroplasty (THA). In addition, we established a nomogram model for POD prediction.MethodsTotally, 254 elderly cases who received THA were included. Clinical and laboratory data of these patients were retrospectively collected. Albumin-associated inflammatory and nutritional markers included neutrophil-to-albumin ratio (NAR), CRP-to-albumin ratio (CAR), prognostic nutritional index (PNI), and systemic inflammation score (SIS). The LASSO, univariate and multivariate logistic regression analyses were utilized to screen risk factors. A nomogram model was developed according to the results of multivariate regression analyses.ResultsAmong 254 patients, 49 cases had POD with an incidence of 19.3%. LASSO regression and multivariate logistic analyses suggested that preoperative NAR, preoperative PNI, preoperative SIS, and age >75 years were risk factors for POD. A nomogram model was developed according to the results of multivariate logistic analyses. The calibration curve suggested that the predicted probability of this nomogram model was in good line with the actual probability. The DCA showed that this nomogram model had net benefits for the prediction of POD for elderly patients following THA.ConclusionAlbumin-associated inflammatory and nutritional markers including NAR, PNI, and SIS could predict POD in elderly patients following THA.https://www.frontiersin.org/articles/10.3389/fnut.2023.1158851/fullpost-operative deliriumtotal hip arthroplastyinflammatory markersnutritional markersnomogram |
| spellingShingle | Wenhao Hu Ziyi Song Houlai Shang Jingcheng Wang Yuedong Hao Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty Frontiers in Nutrition post-operative delirium total hip arthroplasty inflammatory markers nutritional markers nomogram |
| title | Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty |
| title_full | Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty |
| title_fullStr | Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty |
| title_full_unstemmed | Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty |
| title_short | Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty |
| title_sort | inflammatory and nutritional markers predict the risk of post operative delirium in elderly patients following total hip arthroplasty |
| topic | post-operative delirium total hip arthroplasty inflammatory markers nutritional markers nomogram |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1158851/full |
| work_keys_str_mv | AT wenhaohu inflammatoryandnutritionalmarkerspredicttheriskofpostoperativedeliriuminelderlypatientsfollowingtotalhiparthroplasty AT ziyisong inflammatoryandnutritionalmarkerspredicttheriskofpostoperativedeliriuminelderlypatientsfollowingtotalhiparthroplasty AT houlaishang inflammatoryandnutritionalmarkerspredicttheriskofpostoperativedeliriuminelderlypatientsfollowingtotalhiparthroplasty AT jingchengwang inflammatoryandnutritionalmarkerspredicttheriskofpostoperativedeliriuminelderlypatientsfollowingtotalhiparthroplasty AT yuedonghao inflammatoryandnutritionalmarkerspredicttheriskofpostoperativedeliriuminelderlypatientsfollowingtotalhiparthroplasty |