Systematic pattern analyses of Vδ2+ TCRs reveal that shared “public” Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status

Systematic pattern analyses of Vδ2+ TCRs reveal that shared “public” Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status

BackgroundVγ9Vδ2+ T cells are a major innate T cell subset in human peripheral blood. Their Vδ2+ VDJ-rearrangements are short and simple in the fetal thymus and gradually increase in diversity and CDR3 length along with development. So-called “public” versions of Vδ2+ TCRs are shared among individua...

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Bibliographic Details
Main Authors: Lihua Deng, Anna Harms, Sarina Ravens, Immo Prinz, Likai Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
γδ TCR
Vγ9Vδ2+ T cells
TCR distance
TCR sequencing
TRD rearrangement
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.960920/full

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