Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer’s disease
Although there are still no satisfactory answers to the question of why we need to sleep, a better understanding of its function will help to improve societal attitudes toward sleep. Sleep disorders are very common in neurodegenerative diseases and are a key factor in the quality of life of patients...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.944283/full |
| _version_ | 1798039873720942592 |
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| author | Xiangyang Xiong Tianpeng Hu Zhenyu Yin Yaodan Zhang Fanglian Chen Ping Lei |
| author_facet | Xiangyang Xiong Tianpeng Hu Zhenyu Yin Yaodan Zhang Fanglian Chen Ping Lei |
| author_sort | Xiangyang Xiong |
| collection | DOAJ |
| description | Although there are still no satisfactory answers to the question of why we need to sleep, a better understanding of its function will help to improve societal attitudes toward sleep. Sleep disorders are very common in neurodegenerative diseases and are a key factor in the quality of life of patients and their families. Alzheimer’s disease (AD) is an insidious and irreversible neurodegenerative disease. Along with progressive cognitive impairment, sleep disorders and disturbances in circadian rhythms play a key role in the progression of AD. Sleep and circadian rhythm disturbances are more common in patients with AD than in the general population and can appear early in the course of the disease. Therefore, this review discusses the bidirectional relationships among circadian rhythm disturbances, sleep disorders, and AD. In addition, pharmacological and non-pharmacological treatment options for patients with AD and sleep disorders are outlined. |
| first_indexed | 2024-04-11T21:59:41Z |
| format | Article |
| id | doaj.art-963c585f185d44e39964cf47003a3624 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T21:59:41Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-963c585f185d44e39964cf47003a36242022-12-22T04:01:00ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.944283944283Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer’s diseaseXiangyang Xiong0Tianpeng Hu1Zhenyu Yin2Yaodan Zhang3Fanglian Chen4Ping Lei5Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Geriatrics, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Geriatrics, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Geriatrics, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Neurological Institute, Tianjin, ChinaDepartment of Geriatrics, Tianjin Medical University General Hospital, Tianjin, ChinaAlthough there are still no satisfactory answers to the question of why we need to sleep, a better understanding of its function will help to improve societal attitudes toward sleep. Sleep disorders are very common in neurodegenerative diseases and are a key factor in the quality of life of patients and their families. Alzheimer’s disease (AD) is an insidious and irreversible neurodegenerative disease. Along with progressive cognitive impairment, sleep disorders and disturbances in circadian rhythms play a key role in the progression of AD. Sleep and circadian rhythm disturbances are more common in patients with AD than in the general population and can appear early in the course of the disease. Therefore, this review discusses the bidirectional relationships among circadian rhythm disturbances, sleep disorders, and AD. In addition, pharmacological and non-pharmacological treatment options for patients with AD and sleep disorders are outlined.https://www.frontiersin.org/articles/10.3389/fnagi.2022.944283/fullsleep disorderscircadian rhythm disturbancesAlzheimer’s diseaseamyloid-βtau |
| spellingShingle | Xiangyang Xiong Tianpeng Hu Zhenyu Yin Yaodan Zhang Fanglian Chen Ping Lei Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer’s disease Frontiers in Aging Neuroscience sleep disorders circadian rhythm disturbances Alzheimer’s disease amyloid-β tau |
| title | Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer’s disease |
| title_full | Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer’s disease |
| title_fullStr | Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer’s disease |
| title_full_unstemmed | Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer’s disease |
| title_short | Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer’s disease |
| title_sort | research advances in the study of sleep disorders circadian rhythm disturbances and alzheimer s disease |
| topic | sleep disorders circadian rhythm disturbances Alzheimer’s disease amyloid-β tau |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.944283/full |
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