Airway remodeling: The Drosophila model permits a purely epithelial perspective
Airway remodeling is an umbrella term for structural changes in the conducting airways that occur in chronic inflammatory lung diseases such as asthma or chronic obstructive pulmonary disease (COPD). The pathobiology of remodeling involves multiple mesenchymal and lymphoid cell types and finally lea...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2022.876673/full |
| _version_ | 1818050111706497024 |
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| author | Birte Ehrhardt Natalia El-Merhie Draginja Kovacevic Juliana Schramm Judith Bossen Thomas Roeder Susanne Krauss-Etschmann Susanne Krauss-Etschmann |
| author_facet | Birte Ehrhardt Natalia El-Merhie Draginja Kovacevic Juliana Schramm Judith Bossen Thomas Roeder Susanne Krauss-Etschmann Susanne Krauss-Etschmann |
| author_sort | Birte Ehrhardt |
| collection | DOAJ |
| description | Airway remodeling is an umbrella term for structural changes in the conducting airways that occur in chronic inflammatory lung diseases such as asthma or chronic obstructive pulmonary disease (COPD). The pathobiology of remodeling involves multiple mesenchymal and lymphoid cell types and finally leads to a variety of hardly reversible changes such as hyperplasia of goblet cells, thickening of the reticular basement membrane, deposition of collagen, peribronchial fibrosis, angiogenesis and hyperplasia of bronchial smooth muscle cells. In order to develop solutions for prevention or innovative therapies, these complex processes must be understood in detail which requires their deconstruction into individual building blocks. In the present manuscript we therefore focus on the role of the airway epithelium and introduce Drosophila melanogaster as a model. The simple architecture of the flies’ airways as well as the lack of adaptive immunity allows to focus exclusively on the importance of the epithelium for the remodeling processes. We will review and discuss genetic and environmentally induced changes in epithelial structures and molecular responses and propose an integrated framework of research for the future. |
| first_indexed | 2024-12-10T10:48:17Z |
| format | Article |
| id | doaj.art-963dfbf80f0544efb5f6b162b64e2401 |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-12-10T10:48:17Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj.art-963dfbf80f0544efb5f6b162b64e24012022-12-22T01:52:05ZengFrontiers Media S.A.Frontiers in Allergy2673-61012022-09-01310.3389/falgy.2022.876673876673Airway remodeling: The Drosophila model permits a purely epithelial perspectiveBirte Ehrhardt0Natalia El-Merhie1Draginja Kovacevic2Juliana Schramm3Judith Bossen4Thomas Roeder5Susanne Krauss-Etschmann6Susanne Krauss-Etschmann7Division of Early Life Origins of Chronic Lung Diseases, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, GermanyDivision of Early Life Origins of Chronic Lung Diseases, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, GermanyDivision of Early Life Origins of Chronic Lung Diseases, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, GermanyDivision of Early Life Origins of Chronic Lung Diseases, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, GermanyDivision of Molecular Physiology, Institute of Zoology, Christian-Albrechts University Kiel, Kiel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Kiel, GermanyDivision of Molecular Physiology, Institute of Zoology, Christian-Albrechts University Kiel, Kiel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Kiel, GermanyDivision of Early Life Origins of Chronic Lung Diseases, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, GermanyInstitute of Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, GermanyAirway remodeling is an umbrella term for structural changes in the conducting airways that occur in chronic inflammatory lung diseases such as asthma or chronic obstructive pulmonary disease (COPD). The pathobiology of remodeling involves multiple mesenchymal and lymphoid cell types and finally leads to a variety of hardly reversible changes such as hyperplasia of goblet cells, thickening of the reticular basement membrane, deposition of collagen, peribronchial fibrosis, angiogenesis and hyperplasia of bronchial smooth muscle cells. In order to develop solutions for prevention or innovative therapies, these complex processes must be understood in detail which requires their deconstruction into individual building blocks. In the present manuscript we therefore focus on the role of the airway epithelium and introduce Drosophila melanogaster as a model. The simple architecture of the flies’ airways as well as the lack of adaptive immunity allows to focus exclusively on the importance of the epithelium for the remodeling processes. We will review and discuss genetic and environmentally induced changes in epithelial structures and molecular responses and propose an integrated framework of research for the future.https://www.frontiersin.org/articles/10.3389/falgy.2022.876673/fullDrosophila melanogasterairway epitheliumairway remodelinganimal modelchronic inflammatory lung diseasestrachea |
| spellingShingle | Birte Ehrhardt Natalia El-Merhie Draginja Kovacevic Juliana Schramm Judith Bossen Thomas Roeder Susanne Krauss-Etschmann Susanne Krauss-Etschmann Airway remodeling: The Drosophila model permits a purely epithelial perspective Frontiers in Allergy Drosophila melanogaster airway epithelium airway remodeling animal model chronic inflammatory lung diseases trachea |
| title | Airway remodeling: The Drosophila model permits a purely epithelial perspective |
| title_full | Airway remodeling: The Drosophila model permits a purely epithelial perspective |
| title_fullStr | Airway remodeling: The Drosophila model permits a purely epithelial perspective |
| title_full_unstemmed | Airway remodeling: The Drosophila model permits a purely epithelial perspective |
| title_short | Airway remodeling: The Drosophila model permits a purely epithelial perspective |
| title_sort | airway remodeling the drosophila model permits a purely epithelial perspective |
| topic | Drosophila melanogaster airway epithelium airway remodeling animal model chronic inflammatory lung diseases trachea |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2022.876673/full |
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