Mucosal circadian rhythm pathway genes altered by aging and periodontitis
As circadian processes can impact the immune system and are affected by infections and inflammation, this study examined the expression of circadian rhythm genes in periodontitis. Methods:Macaca mulatta were used with naturally-occurring and ligature-induced periodontitis. Gingival tissue samples we...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9725147/?tool=EBI |
| _version_ | 1797979751537704960 |
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| author | Jeffrey L. Ebersole Octavio A. Gonzalez |
| author_facet | Jeffrey L. Ebersole Octavio A. Gonzalez |
| author_sort | Jeffrey L. Ebersole |
| collection | DOAJ |
| description | As circadian processes can impact the immune system and are affected by infections and inflammation, this study examined the expression of circadian rhythm genes in periodontitis. Methods:Macaca mulatta were used with naturally-occurring and ligature-induced periodontitis. Gingival tissue samples were obtained from healthy, diseased, and resolved sites in four groups: young (≤3 years), adolescent (3–7 years), adult (12–26) and aged (18–23 years). Microarrays targeted circadian rhythm (n = 42), inflammation/tissue destruction (n = 11), bone biology (n = 8) and hypoxia pathway (n = 7) genes. Results: The expression of many circadian rhythm genes, across functional components of the pathway, was decreased in healthy tissues from younger and aged animals, as well as showing significant decreases with periodontitis. Negative correlations of the circadian rhythm gene levels with inflammatory mediators and tissue destructive/remodeling genes were particularly accentuated in disease. A dominance of positive correlations with hypoxia genes was observed, except HIF1A, that was uniformly negatively correlated in health, disease and resolution. Conclusions: The chronic inflammation of periodontitis exhibits an alteration of the circadian rhythm pathway, predominantly via decreased gene expression. Thus, variation in disease expression and the underlying molecular mechanisms of disease may be altered due to changes in regulation of the circadian rhythm pathway functions. |
| first_indexed | 2024-04-11T05:44:39Z |
| format | Article |
| id | doaj.art-963e542b5f204f6db733c830e8ee163a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T05:44:39Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-963e542b5f204f6db733c830e8ee163a2022-12-22T04:42:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011712Mucosal circadian rhythm pathway genes altered by aging and periodontitisJeffrey L. EbersoleOctavio A. GonzalezAs circadian processes can impact the immune system and are affected by infections and inflammation, this study examined the expression of circadian rhythm genes in periodontitis. Methods:Macaca mulatta were used with naturally-occurring and ligature-induced periodontitis. Gingival tissue samples were obtained from healthy, diseased, and resolved sites in four groups: young (≤3 years), adolescent (3–7 years), adult (12–26) and aged (18–23 years). Microarrays targeted circadian rhythm (n = 42), inflammation/tissue destruction (n = 11), bone biology (n = 8) and hypoxia pathway (n = 7) genes. Results: The expression of many circadian rhythm genes, across functional components of the pathway, was decreased in healthy tissues from younger and aged animals, as well as showing significant decreases with periodontitis. Negative correlations of the circadian rhythm gene levels with inflammatory mediators and tissue destructive/remodeling genes were particularly accentuated in disease. A dominance of positive correlations with hypoxia genes was observed, except HIF1A, that was uniformly negatively correlated in health, disease and resolution. Conclusions: The chronic inflammation of periodontitis exhibits an alteration of the circadian rhythm pathway, predominantly via decreased gene expression. Thus, variation in disease expression and the underlying molecular mechanisms of disease may be altered due to changes in regulation of the circadian rhythm pathway functions.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9725147/?tool=EBI |
| spellingShingle | Jeffrey L. Ebersole Octavio A. Gonzalez Mucosal circadian rhythm pathway genes altered by aging and periodontitis PLoS ONE |
| title | Mucosal circadian rhythm pathway genes altered by aging and periodontitis |
| title_full | Mucosal circadian rhythm pathway genes altered by aging and periodontitis |
| title_fullStr | Mucosal circadian rhythm pathway genes altered by aging and periodontitis |
| title_full_unstemmed | Mucosal circadian rhythm pathway genes altered by aging and periodontitis |
| title_short | Mucosal circadian rhythm pathway genes altered by aging and periodontitis |
| title_sort | mucosal circadian rhythm pathway genes altered by aging and periodontitis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9725147/?tool=EBI |
| work_keys_str_mv | AT jeffreylebersole mucosalcircadianrhythmpathwaygenesalteredbyagingandperiodontitis AT octavioagonzalez mucosalcircadianrhythmpathwaygenesalteredbyagingandperiodontitis |