Chronic lead exposure induces fatty liver disease associated with the variations of gut microbiota
Background: Lead (Pb) has been suggested as an endocrine-disrupting chemical. However, few studies have investigated the association between chronic Pb exposure and fatty liver disease. Objectives: We aimed to investigate the association of chronic Pb exposure with fatty liver disease and whether th...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322000975 |
| _version_ | 1819289076311785472 |
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| author | Heng Wan Yuying Wang Haojie Zhang Kun Zhang Yi Chen Chi Chen Wen Zhang Fangzhen Xia Ningjian Wang Yingli Lu |
| author_facet | Heng Wan Yuying Wang Haojie Zhang Kun Zhang Yi Chen Chi Chen Wen Zhang Fangzhen Xia Ningjian Wang Yingli Lu |
| author_sort | Heng Wan |
| collection | DOAJ |
| description | Background: Lead (Pb) has been suggested as an endocrine-disrupting chemical. However, few studies have investigated the association between chronic Pb exposure and fatty liver disease. Objectives: We aimed to investigate the association of chronic Pb exposure with fatty liver disease and whether the variations of the gut microbiota involve in the mechanism of the fatty liver disease induced by chronic Pb exposure. Methods: We conducted a cross-sectional study of 3066 rural participants in East China. Blood lead level (BLL) was detected, and abdominal ultrasonography was used to diagnose hepatic steatosis. Both the definition of non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) were used. Wistar rats were randomly divided into two groups and each group was exposed to 0 or 0.05% w/v Pb through drinking water for 28 weeks. The relevant parameters of hepatic lipid metabolism and gut microbiota were analyzed. Results: In humans, after adjusting for potential confounders, the odds of having NAFLD and MAFLD were significantly increased by 54% and 52% in the participants in the fourth BLL quartile (OR 1.54, 95% CI 1.24, 1.91 and OR 1.52, 95% CI 1.22, 1.89). In the rats, chronic Pb exposure induced the increased visceral fat, hepatic steatosis, and dysbiosis of the gut microbiota, including the decrease of richness, diversity, evenness and phylogenetic diversity of the gut microbiota and the significant alternations of the gut microbiota composition, particularly, the decrease of the relative abundance of Coprococcus and Oscillospira at the genus level. Conclusions: Chronic Pb exposure could induce fatty liver disease, which may be associated with the variations of the gut microbiota. |
| first_indexed | 2024-12-24T03:01:06Z |
| format | Article |
| id | doaj.art-963fd045c50f455b860fe39d019e7f98 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-24T03:01:06Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-963fd045c50f455b860fe39d019e7f982022-12-21T17:18:12ZengElsevierEcotoxicology and Environmental Safety0147-65132022-03-01232113257Chronic lead exposure induces fatty liver disease associated with the variations of gut microbiotaHeng Wan0Yuying Wang1Haojie Zhang2Kun Zhang3Yi Chen4Chi Chen5Wen Zhang6Fangzhen Xia7Ningjian Wang8Yingli Lu9Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China; Institute and Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China; Institute and Department of Endocrinology and Metabolism, Huangpu Branch, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China; Correspondence to: Institute and Department of Endocrinology and Metabolism, Huangpu Branch, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China.Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China; Institute and Department of Endocrinology and Metabolism, Huangpu Branch, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China; Correspondence to: Institute and Department of Endocrinology and Metabolism, Huangpu Branch, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China.Background: Lead (Pb) has been suggested as an endocrine-disrupting chemical. However, few studies have investigated the association between chronic Pb exposure and fatty liver disease. Objectives: We aimed to investigate the association of chronic Pb exposure with fatty liver disease and whether the variations of the gut microbiota involve in the mechanism of the fatty liver disease induced by chronic Pb exposure. Methods: We conducted a cross-sectional study of 3066 rural participants in East China. Blood lead level (BLL) was detected, and abdominal ultrasonography was used to diagnose hepatic steatosis. Both the definition of non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) were used. Wistar rats were randomly divided into two groups and each group was exposed to 0 or 0.05% w/v Pb through drinking water for 28 weeks. The relevant parameters of hepatic lipid metabolism and gut microbiota were analyzed. Results: In humans, after adjusting for potential confounders, the odds of having NAFLD and MAFLD were significantly increased by 54% and 52% in the participants in the fourth BLL quartile (OR 1.54, 95% CI 1.24, 1.91 and OR 1.52, 95% CI 1.22, 1.89). In the rats, chronic Pb exposure induced the increased visceral fat, hepatic steatosis, and dysbiosis of the gut microbiota, including the decrease of richness, diversity, evenness and phylogenetic diversity of the gut microbiota and the significant alternations of the gut microbiota composition, particularly, the decrease of the relative abundance of Coprococcus and Oscillospira at the genus level. Conclusions: Chronic Pb exposure could induce fatty liver disease, which may be associated with the variations of the gut microbiota.http://www.sciencedirect.com/science/article/pii/S0147651322000975Blood lead levelLead exposureFatty liver diseaseGut microbiota |
| spellingShingle | Heng Wan Yuying Wang Haojie Zhang Kun Zhang Yi Chen Chi Chen Wen Zhang Fangzhen Xia Ningjian Wang Yingli Lu Chronic lead exposure induces fatty liver disease associated with the variations of gut microbiota Ecotoxicology and Environmental Safety Blood lead level Lead exposure Fatty liver disease Gut microbiota |
| title | Chronic lead exposure induces fatty liver disease associated with the variations of gut microbiota |
| title_full | Chronic lead exposure induces fatty liver disease associated with the variations of gut microbiota |
| title_fullStr | Chronic lead exposure induces fatty liver disease associated with the variations of gut microbiota |
| title_full_unstemmed | Chronic lead exposure induces fatty liver disease associated with the variations of gut microbiota |
| title_short | Chronic lead exposure induces fatty liver disease associated with the variations of gut microbiota |
| title_sort | chronic lead exposure induces fatty liver disease associated with the variations of gut microbiota |
| topic | Blood lead level Lead exposure Fatty liver disease Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322000975 |
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