Intradermal immunization with botulinum neurotoxin serotype E DNA vaccine induces humoral and cellular immunity and protects against lethal toxin challenge

Intradermal immunization with botulinum neurotoxin serotype E DNA vaccine induces humoral and cellular immunity and protects against lethal toxin challenge

Botulinum neurotoxins (BoNTs) produced by the spore-forming, gram-positive, anaerobic bacterium Clostridium botulinum are the most toxic substances known and cause botulism, flaccid paralysis, or death. Owing to their high lethality, BoNTs are classified as category A agents by the Centers for Disea...

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Bibliographic Details
Main Authors: Na Young Kim, Hye Bin Ahn, Chi Ho Yu, Dong Hyun Song, Gyeung Haeng Hur, Young Kee Shin, Sungho Shin
Format: Article
Language:English
Published: Taylor & Francis Group 2019-02-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
botulinum neurotoxin e
dna vaccine
intradermal delivery
immune response
protection
Online Access:http://dx.doi.org/10.1080/21645515.2018.1526554

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