Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice
Traumatic optic neuropathy (TON) is the loss of vision secondary to trauma. Approximately two weeks after traumatic damage, diffuse retinal ganglion cell loss and axon degeneration of the optic nerve are exhibited [1]. Here we present the changes that occur in the optic nerve lipidome of two-month-o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-04-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235234092030041X |
| _version_ | 1819102917264670720 |
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| author | Ronaldo Nuesi Ryan A. Gallo Galina Dvoriantchikova Daniel Pelaez Sanjoy K. Bhattacharya |
| author_facet | Ronaldo Nuesi Ryan A. Gallo Galina Dvoriantchikova Daniel Pelaez Sanjoy K. Bhattacharya |
| author_sort | Ronaldo Nuesi |
| collection | DOAJ |
| description | Traumatic optic neuropathy (TON) is the loss of vision secondary to trauma. Approximately two weeks after traumatic damage, diffuse retinal ganglion cell loss and axon degeneration of the optic nerve are exhibited [1]. Here we present the changes that occur in the optic nerve lipidome of two-month-old C57BL/6J mice following sonication-induced TON (SI-TON), which closely models the indirect clinical mechanism in TON. Optic nerves were harvested at three time points following injury: 1-day, 7-days, and 14-days for comparison with the control group (uninjured optic nerves from 2-month-old mice). The optic nerves were subjected to mass spectrometry and bioinformatic analysis using LipidSearch 4.1.3 and Metaboanalyst 4.0. This data pertains to the lipidome at each time point following indirect trauma to the optic nerve. The data presented here will augment investigation into the neurodegenerative process. The data is available at Metabolomics Workbench [http://www.metabolomicsworkbench.org (Project ID: PR000859)]. Keywords: Traumatic optic neuropathy, Optic nerve injury, Lipid profile, Liquid chromatography-mass spectrometry, Metabolomics, Neurodegeneration |
| first_indexed | 2024-12-22T01:42:11Z |
| format | Article |
| id | doaj.art-964608fca9bb4cba988f9fd0af9ef1c8 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-22T01:42:11Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-964608fca9bb4cba988f9fd0af9ef1c82022-12-21T18:43:10ZengElsevierData in Brief2352-34092020-04-0129Lipidomics dataset of sonication-induced traumatic optic neuropathy in miceRonaldo Nuesi0Ryan A. Gallo1Galina Dvoriantchikova2Daniel Pelaez3Sanjoy K. Bhattacharya4Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, 33136, USABascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, 33136, USABascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, 33136, USACorresponding author.; Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, 33136, USACorresponding author.; Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, 33136, USATraumatic optic neuropathy (TON) is the loss of vision secondary to trauma. Approximately two weeks after traumatic damage, diffuse retinal ganglion cell loss and axon degeneration of the optic nerve are exhibited [1]. Here we present the changes that occur in the optic nerve lipidome of two-month-old C57BL/6J mice following sonication-induced TON (SI-TON), which closely models the indirect clinical mechanism in TON. Optic nerves were harvested at three time points following injury: 1-day, 7-days, and 14-days for comparison with the control group (uninjured optic nerves from 2-month-old mice). The optic nerves were subjected to mass spectrometry and bioinformatic analysis using LipidSearch 4.1.3 and Metaboanalyst 4.0. This data pertains to the lipidome at each time point following indirect trauma to the optic nerve. The data presented here will augment investigation into the neurodegenerative process. The data is available at Metabolomics Workbench [http://www.metabolomicsworkbench.org (Project ID: PR000859)]. Keywords: Traumatic optic neuropathy, Optic nerve injury, Lipid profile, Liquid chromatography-mass spectrometry, Metabolomics, Neurodegenerationhttp://www.sciencedirect.com/science/article/pii/S235234092030041X |
| spellingShingle | Ronaldo Nuesi Ryan A. Gallo Galina Dvoriantchikova Daniel Pelaez Sanjoy K. Bhattacharya Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice Data in Brief |
| title | Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice |
| title_full | Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice |
| title_fullStr | Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice |
| title_full_unstemmed | Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice |
| title_short | Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice |
| title_sort | lipidomics dataset of sonication induced traumatic optic neuropathy in mice |
| url | http://www.sciencedirect.com/science/article/pii/S235234092030041X |
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