Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria

Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria

ABSTRACT Therapeutic options to treat bacterial infections caused by Gram-negative pathogens are limited due to the spread of multidrug resistance. Protein engineering of phage-derived lysins can play a key role in the search for new antimicrobial compounds targeting Gram-negative pathogens. A previ...

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Bibliographic Details
Main Authors: Hans Gerstmans, Lisa Duyvejonck, Roberto Vázquez, Ines Staes, Jimmy Borloo, Karim Abdelkader, Jeroen Leroy, Emma Cremelie, Diana Gutiérrez, Héctor Tamés-Caunedo, Patricia Ruas-Madiedo, Ana Rodríguez, Abram Aertsen, Jeroen Lammertyn, Rob Lavigne, Yves Briers
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
lysin
mode of action
Acinetobacter baumannii
serum
osmotic lysis
thermoresistance
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01813-23

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